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Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila: cloning, characterization and differential expression in tissues and by stress compounds.
- Y. Yamazaki, H. Sudo, M. Yamazaki, N. Aimi, K. Saito
- Biology, Medicine
- Plant & cell physiology
- 15 April 2003
Camptothecin derivatives are clinically used anti-tumor compounds that biogenetically belong to a group of monoterpenoid indole alkaloids (TIA). We have already established a hairy root culture of… Expand
A New Indole Alkaloid, 7 α-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand
Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L.
Abstract Phytochemical and bioactivity studies of the flowers of Melastoma malabathricum L. (Melastomataceae) have been carried out. The ethyl acetate extract yielded three compounds, identified as… Expand
A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand.
Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range
- Y. Kobayashi, Y. Ogra, K. Ishiwata, H. Takayama, N. Aimi, K. Suzuki
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 19 November 2002
Essential micronutrient selenium is excreted into the urine and/or expired after being transformed to methylated metabolites. Monomethylated selenium is excreted into the urine in response to a… Expand
Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
7-Hydroxymitragynine is a potent opioid analgesic alkaloid isolated from the Thai medicinal herb Mitragyna speciosa. In the present study, we investigated the opioid receptor subtype responsible for… Expand
Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa.
Mitragynine is an indole alkaloid isolated from the Thai medicinal plant Mitragyna speciosa. We previously reported the morphine-like action of mitragynine and its related compounds in the in vitro… Expand
Bioreactor production of camptothecin by hairy root cultures of Ophiorrhiza pumila
A large-scale culture of hairy root of Ophiorrhiza pumila using a modified 3 l bioreactor was established. The hairy roots, incited by infection of Agrobacterium rhizogenes were grown in the… Expand
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
- H. Takayama, H. Ishikawa, +10 authors S. Horie
- Chemistry, Medicine
- Journal of medicinal chemistry
- 20 March 2002
Mitragynine (1) is a major alkaloidal component in the Thai traditional medicinal herb, Mitragyna speciosa, and has been proven to exhibit analgesic activity mediated by opioid receptors. By… Expand
Lyngbyatoxins B and C, two new irritants from Lyngbya majuscula.