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Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)
Several species of the genus Artocarpus (Moraceae) have been investigated in our laboratories during the last decade. Over 60 phenolic constituents have been discovered and characterized, including… Expand
A New Indole Alkaloid, 7 α-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand
Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant “kratom” (Mitragyna speciosa) by LC-ESI-MS
- R. Kikura-Hanajiri, Maiko Kawamura, T. Maruyama, M. Kitajima, H. Takayama, Y. Goda
- Forensic Toxicology
- 9 May 2009
The leaves of Mitragyna speciosa, a tropical plant known as “kratom,” have been traditionally used as a substitute for opium in Thailand and Malaysia. Mitragynine, a major constituent of M. speciosa,… Expand
Antioxidant and cytotoxic flavonoids from the flowers of Melastoma malabathricum L.
Abstract Phytochemical and bioactivity studies of the flowers of Melastoma malabathricum L. (Melastomataceae) have been carried out. The ethyl acetate extract yielded three compounds, identified as… Expand
A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand.
Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
7-hydroxymitragynine, a constituent of the Thai herbal medicine Mitragyna speciosa, has been found to have a potent opioid antinociceptive effect. In the present study, we investigated the mechanism… Expand
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
- H. Takayama, H. Ishikawa, +10 authors S. Horie
- Chemistry, Medicine
- Journal of medicinal chemistry
- 20 March 2002
Mitragynine (1) is a major alkaloidal component in the Thai traditional medicinal herb, Mitragyna speciosa, and has been proven to exhibit analgesic activity mediated by opioid receptors. By… Expand
New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives.
- Y. Toriizuka, Eri Kinoshita, +6 authors H. Takayama
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 December 2008
A new lycorine derivative LT1 (4) was isolated from the aerial part and bulbs of Lycoris traubii Hayward (Amaryllidaceae). Its structure including absolute configuration was established by… Expand
Metabolic profiling of flavonoids in Lotus japonicus using liquid chromatography Fourier transform ion cyclotron resonance mass spectrometry.
Flavonoids detected from a model legume plant, Lotus japonicus accessions Miyakojima MG-20 and Gifu B-129, were profiled using liquid chromatography Fourier transform ion cyclotron resonance mass… Expand
Anthraquinones from Morinda elliptica
Phytochemical studies on roots of Morinda elliptica have resulted in the isolation of a new anthraquinone, 2-formyl-1-hydroxyanthraquinone, and 10 known anthraquinones. The structures of the… Expand