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Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)
TLDR
The structures of the new and unusual natural products are presented, including 27 new compounds from 13 Indonesian taxa of Artocarpus, which exhibit cytotoxic effect against murine leukemia P388 cells and may further rearrange into xanthone to produce various classes of natural products.
Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant “kratom” (Mitragyna speciosa) by LC-ESI-MS
The leaves of Mitragyna speciosa, a tropical plant known as “kratom,” have been traditionally used as a substitute for opium in Thailand and Malaysia. Mitragynine, a major constituent of M. speciosa,
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
TLDR
The oxidative derivatives of mitragynine were found as opioid agonists with higher potency than morphine in the experiment with guinea pig ileum, and 2 induced an analgesic activity in the tail flick test in mice.
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