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Comprehensive Flavonol Profiling and Transcriptome Coexpression Analysis Leading to Decoding Gene–Metabolite Correlations in Arabidopsis[W][OA]
TLDR
The precise identification of flavonoids in conjunction with transcriptomics led to the identification of a gene function and a more complete understanding of a plant metabolic network.
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Chemistry and pharmacology of analgesic indole alkaloids from the rubiaceous plant, Mitragyna speciosa.
  • H. Takayama
  • Chemistry, Biology
    Chemical & pharmaceutical bulletin
  • 1 August 2004
TLDR
The potent opioid agonistic activities of mitragynine, the major constituent of this plant, and its analogues were found in in vitro and in vivo experiments and the mechanisms underlying the analgesic activity were clarified, and 7-hydroxymitragynines, a minor constituent of M. speciosa, was found to exhibit potent antinociceptive activity in mice.
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Prenylated flavonoids and related compounds of the Indonesian Artocarpus (Moraceae)
TLDR
The structures of the new and unusual natural products are presented, including 27 new compounds from 13 Indonesian taxa of Artocarpus, which exhibit cytotoxic effect against murine leukemia P388 cells and may further rearrange into xanthone to produce various classes of natural products.
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A New Indole Alkaloid, 7 α-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand
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Simultaneous analysis of mitragynine, 7-hydroxymitragynine, and other alkaloids in the psychotropic plant “kratom” (Mitragyna speciosa) by LC-ESI-MS
The leaves of Mitragyna speciosa, a tropical plant known as “kratom,” have been traditionally used as a substitute for opium in Thailand and Malaysia. Mitragynine, a major constituent of M. speciosa,…
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Antinociception, tolerance and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
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Dimethylthioarsenicals as arsenic metabolites and their chemical preparations.
TLDR
Two unidentified arsenic metabolites were detected in the liver of rats on a gel filtration column by HPLC inductively coupled argon plasma mass spectrometry after an injection of dimethylarsinic (DMA(V), dimethyldithioarsinic acid (dimethylarsinodithioic acid) (DMTA(V)) and dimethylthioarsinous acid ( DMTA(III).
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Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range
TLDR
Urinary monomethylated (selenosugar) and trimethylated selenium can be used as specific indices that increase within the required to low-toxic range and with a distinct toxic dose, respectively.
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A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand.
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Involvement of mu-opioid receptors in antinociception and inhibition of gastrointestinal transit induced by 7-hydroxymitragynine, isolated from Thai herbal medicine Mitragyna speciosa.
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