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Expression of an antitumor-analgesic peptide from the venom of Chinese scorpion Buthus martensii karsch in Escherichia coli.
Philippine tests showed that the recombinant AGAP has both analgesic and antitumor activities on mice and was purified to homogeneity by metal chelating affinity chromatography.
p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells.
Shikonin-induced DNA damage activates p53 and caspase-9 pathways, and this activity is related to cell cycle arrest and apoptosis in tumor cell lines.
Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways.
This study showed that oridonin stimulated mitochondrial transmembrane permeabilization in a ROS-dependent manner because NAC almost thoroughly reversed the drop of mitochondrial trans Membrane potential (Deltapsim) and the release of cytochrome c from the mitochondrial inter-membranes space into cytosol.
Microbial transformation of ginsenoside Rb1 by Acremonium strictum
It is demonstrated that microbial culture parallels mammalian metabolism; therefore, A. strictum might be a useful tool for generating mammalian metabolites of related analogs of ginsenosides for complete structural identification and for further use in pharmaceutical research in this series of compounds.
(+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest.
Extracts of Chinese herbs have been demonstrated to inhibit oxidative stress in vitro. In this study, we investigated the mechanism of (+)-catechin, isolated from green tea, which preserved murine
Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1.
Results demonstrate that silibinin protects against isoproterenol-induced cardiac myocytes injury through resuming mitochondrial function and regulating the expression of SIRT1 and Bcl-2 family members.
Curcumin inhibits lung cancer cell migration and invasion through Rac1-dependent signaling pathway.
It is demonstrated that low-toxic levels of curcumin could efficiently inhibit migration and invasion of lung cancer cells through inhibition of Rac1/PAK1 signaling pathway and MMP-2 and M MP-9 expression, which provided a novel insight into the molecular mechanism ofCurcumin against lung cancer.
Lysosomal membrane permeabilization is involved in curcumin-induced apoptosis of A549 lung carcinoma cells
Findings indicated a novel pathway for curcumin regulation of ROS-lysosomal–mitochondrial pathway and provided the key mechanism of regulation of LMP in cell apoptosis, which may be exploited for cancer treatment.
Silibinin protects rat cardiac myocyte from isoproterenol-induced DNA damage independent on regulation of cell cycle.
Result of flowcytometric analysis showed that the cell cycle was not affected, and the expression of cell cycle regulatory protein p21 also had no change, Consequently, silibinin protected cardiac myocytes against isoproterenol-induced DNA damage through caspase pathway and theexpression of p53, but independent on regulation ofcell cycle.
Constituents with α-glucosidase and advanced glycation end-product formation inhibitory activities from Salvia miltiorrhiza Bge.
The 75% ethanol extract from roots of Salvia miltiorrhiza Bge. (Dan shen) afforded two new compounds, 3-hydroxy-2-(2′-formyloxy-1′-methylethyl)-8-methyl-1,4-phenanthrenedione (1),