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kistrin

 
National Institutes of Health

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Related topics

3 relations

Broader (3)

Fibrinolytic AgentsPeptidesPlatelet Aggregation Inhibitors

Papers overview

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2001
2001
The Disintegrin Kistrin Inhibits Neurite Extension from Spiral Ganglion Explants Cultured on Laminin
The influence of laminin-1 (LN) and tenascin-C (TN), extracellular matrix molecules expressed spatially and temporally along the… Expand
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1997
1997
An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of…
Integrin ligands almost invariably employ a variant of either the RGD or LDV motif as a key element of their receptor recognition… Expand
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Highly Cited
1996
Highly Cited
1996
Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.
Smooth muscle cells (SMCs) have been shown to migrate in response to insulin-like growth factor I (IGF-I). However, the mechanism… Expand
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1994
1994
Effects of kistrin on bone resorption in vitro and serum calcium in vivo.
In many cell systems, cell-cell and cell-matrix interactions are mediated by integrins, a family of cell surface heterodimeric… Expand
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1993
1993
Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules.
Recent data indicate that megakaryocyte/platelet alpha-granule fibrinogen is endocytosed from plasma. Because fibrinogen is the… Expand
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1993
1993
Binding interactions of kistrin with platelet glycoprotein IIb-IIIa: analysis by site-directed mutagenesis.
The binding interactions between platelet fibrinogen receptor, glycoprotein (GP) IIb-IIIa, and kistrin, a snake venom disintegrin… Expand
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1992
1992
Cyclic RGD peptide analogues as antiplatelet antithrombotics.
Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in… Expand
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1991
1991
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent… Expand
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1991
1991
Kistrin, a polypeptide platelet GPIIb/IIIa receptor antagonist, enhances and sustains coronary arterial thrombolysis with recombinant tissue-type plasminogen activator in a canine preparation.
BACKGROUND Kistrin is a 68-amino acid polypeptide from the venom of the Malayan pit viper Agkistrodon rhodostoma, which inhibits… Expand
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Highly Cited
1990
Highly Cited
1990
Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors.
The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins… Expand
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