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kistrin

National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Fibrinolytic AgentsPeptidesPlatelet Aggregation Inhibitors

Papers overview

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Highly Cited
1997
Highly Cited
1997
An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity
Integrin ligands almost invariably employ a variant of either the RGD or LDV motif as a key element of their receptor recognition… Expand
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Highly Cited
1996
Highly Cited
1996
Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor.
Smooth muscle cells (SMCs) have been shown to migrate in response to insulin-like growth factor I (IGF-I). However, the mechanism… Expand
1994
1994
Effects of kistrin on bone resorption in vitro and serum calcium in vivo
In many cell systems, cell‐cell and cell‐matrix interactions are mediated by integrins, a family of cell surface heterodimeric… Expand
Highly Cited
1993
Highly Cited
1993
Binding interactions of kistrin with platelet glycoprotein IIb‐IIIa: Analysis by site‐directed mutagenesis
The binding interactions between platelet fibrinogen receptor, glycoprotein (GP) IIb‐IIIa, and kistrin, a snake venom disintegrin… Expand
1993
1993
Kistrin, an integrin antagonist, blocks endocytosis of fibrinogen into guinea pig megakaryocyte and platelet alpha-granules.
Recent data indicate that megakaryocyte/platelet alpha-granule fibrinogen is endocytosed from plasma. Because fibrinogen is the… Expand
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1993
1993
Cysteine pairing in the glycoprotein IIbIIIa antagonist kistrin using NMR, chemical analysis, and structure calculations.
The pairing of the cysteines in disulfide bonds was investigated for the 68-residue RGD-containing protein kistrin, a potent… Expand
Highly Cited
1992
Highly Cited
1992
Cyclic RGD peptide analogues as antiplatelet antithrombotics.
Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in… Expand
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Highly Cited
1991
Highly Cited
1991
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist.
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent… Expand
Highly Cited
1991
Highly Cited
1991
Kistrin, a Polypeptide Platelet GPIIb/IIIa Receptor Antagonist, Enhances and Sustains Coronary Arterial Thrombolysis With Recombinant Tissue‐Type Plasminogen Activator in a Canine Preparation
BackgroundKistrin is a 68-amino acid polypeptide from the venom of the Malayan pit viper Agkistrodon rhodostoma, which inhibits… Expand
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Highly Cited
1990
Highly Cited
1990
Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors.
The purification, complete amino acid sequence, and biological activity are described for several homologous snake venom proteins… Expand
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