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Identification of RIP1 kinase as a specific cellular target of necrostatins.
Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the form of death domain receptor engagement by their respective ligands under conditions where apoptotic… Expand
Solution Structure of the Integral Human Membrane Protein VDAC-1 in Detergent Micelles
- S. Hiller, R. Garces, Thomas J. Malia, V. Orekhov, M. Colombini, G. Wagner
- Chemistry, Medicine
- 29 August 2008
The voltage-dependent anion channel (VDAC) mediates trafficking of small molecules and ions across the eukaryotic outer mitochondrial membrane. VDAC also interacts with antiapoptotic proteins from… Expand
Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which glucose-derived metabolic fluxes are used for alternative processes is poorly understood. Using a… Expand
An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
The sterol regulatory element binding protein (SREBP) family of transcription activators are critical regulators of cholesterol and fatty acid homeostasis. We previously demonstrated that human… Expand
Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins.
- F. Hagn, M. Etzkorn, Thomas Raschle, G. Wagner
- Chemistry, Medicine
- Journal of the American Chemical Society
- 6 February 2013
Structural studies of membrane proteins are still hampered by difficulties of finding appropriate membrane-mimicking media that maintain protein structure and function. Phospholipid nanodiscs seem… Expand
The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments.
- Jens C. Schmidt, H. Arthanari, +10 authors I. Cheeseman
- Biology, Physics
- Developmental cell
- 1 October 2012
To ensure equal chromosome segregation during mitosis, the macromolecular kinetochore must remain attached to depolymerizing microtubules, which drive chromosome movements. How kinetochores associate… Expand
Solution Structure of BID, an Intracellular Amplifier of Apoptotic Signaling
We report the solution structure of BID, an intracellular cross-talk agent that can amplify FAS/TNF apoptotic signal through the mitochondria death pathway after Caspase 8 cleavage. BID contains… Expand
HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane.
Although rarely elicited during natural human infection, the most broadly neutralizing antibodies (BNAbs) against diverse human immunodeficiency virus (HIV)-1 strains target the membrane-proximal… Expand
The PHD Finger of the Chromatin-Associated Protein ING2 Functions as a Nuclear Phosphoinositide Receptor
Phosphoinositides (PtdInsPs) play critical roles in cytoplasmic signal transduction pathways. However, their functions in the nucleus are unclear, as specific nuclear receptors for PtdInsPs have not… Expand
Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1α
- S. J. Freedman, Z. Sun, +4 authors M. Eck
- Chemistry, Biology
- Proceedings of the National Academy of Sciences…
- 16 April 2002
Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the… Expand