• Publications
  • Influence
Hearing sensitivity of the mongolian gerbil, Meriones unguiculatis.
  • A. Ryan
  • Physics, Medicine
  • The Journal of the Acoustical Society of America
  • 1 May 1976
Mongolian gerbils were trained to respond to pure tones in a shock‐avoidance task. The animals proved to be readily trainable and behaviorally stable. Thresholds were obtained by a method of limitsExpand
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Distribution of the P2X2 receptor subunit of the ATP‐gated ion channels in the rat central nervous system
The distribution of the P2X2 receptor subunit of the adenosine 5′‐triphosphate (ATP)‐gated ion channels was examined in the adult rat central nervous system (CNS) by using P2X2 receptor‐specificExpand
  • 259
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Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus.
We identified Eyes absent 4 (EYA4), a member of the vertebrate Eya family of transcriptional activators, as the causative gene of postlingual, progressive, autosomal dominant hearing loss at theExpand
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Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons
SPECIFIC families of transcription factors mediate events in the sequential maturation of distinct neuronal phenotypes. Members of one such family, the class IV POU domain transcription factorExpand
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Rapid muscle-specific gene expression changes after a single bout of eccentric contractions in the mouse.
Eccentric contractions (ECs), in which a muscle is forced to lengthen while activated, result in muscle injury and, eventually, muscle strengthening and prevention of further injury. Although theExpand
  • 146
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  • PDF
Evidence for differential regulation of calcium by outer versus inner hair cells: plasma membrane Ca-ATPase gene expression
The expression of mRNA encoding plasma membrane calcium ATPase (PMCA) subunit isoforms (1-4) and splice variants was examined in the adult and developing rat cochlea by PCR and in situ hybridization.Expand
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Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise
  • D. Yan, Y. Zhu, +19 authors X. Liu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 23 January 2013
Age-related hearing loss and noise-induced hearing loss are major causes of human morbidity. Here we used genetics and functional studies to show that a shared cause of these disorders may be loss ofExpand
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The development of auditory function in the cochlea of the mongolian gerbil
Cochlear microphonic (CM) potentials were recorded throughout the development of auditory function in the Mongolian gerbil. CM responses were first recorded at 12 days after birth (DAB), withExpand
  • 152
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Expression of the P2X2 Receptor Subunit of the ATP-Gated Ion Channel in the Cochlea: Implications for Sound Transduction and Auditory Neurotransmission
Extracellular ATP has multimodal actions in the cochlea affecting hearing sensitivity. ATP-gated ion channels involved in this process were characterized in the guinea pig cochlea. Voltage-clampedExpand
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Activation of TLR2 by a small molecule produced by Staphylococcus epidermidis increases antimicrobial defense against bacterial skin infections.
  • Y. Lai, A. Cogen, +6 authors R. Gallo
  • Medicine, Biology
  • The Journal of investigative dermatology
  • 1 September 2010
Production of antimicrobial peptides by epithelia is an essential defense against infectious pathogens. In this study we evaluated whether the commensal microorganism Staphylococcus epidermidis mayExpand
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