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From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I.
TLDR
The term "vulnerable patient" may be more appropriate and is proposed now for the identification of subjects with high likelihood of developing cardiac events in the near future and a quantitative method for cumulative risk assessment of vulnerable patients needs to be developed. Expand
The insulin-like growth factor axis: A review of atherosclerosis and restenosis.
TLDR
Understanding IGF axis regulation establishes a scientific basis for strategies directed to limit or reverse plaque growth and vulnerability in atherosclerosis and in the neointimal hyperplasia of restenosis. Expand
Diagnostic accuracy of fractional flow reserve from anatomic CT angiography.
TLDR
Although the study did not achieve its prespecified primary outcome goal for the level of per-patient diagnostic accuracy, use of noninvasive FFR(CT) plus CT among stable patients with suspected or known CAD was associated with improved diagnostic accuracy and discrimination vs CT alone for the diagnosis of hemodynamically significant coronary stenosis. Expand
Continuous-scale physical functional performance in healthy older adults: a validation study.
TLDR
The CS-PFP domain scores were significantly correlated with measures of maximal physical performance and with physical but not emotional aspects of self-perceived function and is applicable to a wide range of functional levels, and having minimal floor and ceiling effect. Expand
Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model.
TLDR
The severity of vessel injury strongly correlated with neointimal thickness and percent diameter stenosis and Neointimal proliferation resulting from a given wire was related to injury severity in adjacent wires, suggesting an interaction among effects at injured sites. Expand
Effect of endurance exercise training on heart rate variability at rest in healthy young and older men.
TLDR
Exercise training increases parasympathetic tone at rest in both the healthy older and young men, which may contribute to the reduction in mortality associated with regular exercise. Expand
Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative study.
TLDR
This histopathologic study confirms an intimate relation between whole heart, coronary artery, and segmental coronary atherosclerotic plaque area and EBCT coronary calcium area but suggests that there is a threshold value for plaque area below which coronary calcium is either absent or not detectable by this methodology. Expand
Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial.
TLDR
Regular exercise such as brisk walking results in reduced body weight and body fat among overweight and obese postmenopausal women. Expand
Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology.
TLDR
Coronary calcium quantification is an excellent method of assessing atherosclerotic plaque presence at individual artery sites and the remodeling phenomenon is the likely explanation for the lack of a good predictive value between lumen narrowing and quantification of mural calcification. Expand
From Vulnerable Plaque to Vulnerable Patient—Part III: Executive Summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force Report
TLDR
The Screening for Heart Attack Prevention and Education (SHAPE) Task Force presents a new practice guideline for cardiovascular screening in the asymptomatic at-risk population, calling for noninvasive screening of all asymptonomatic men 45‐75 years of age and asymPTomatic women 55‐75years of age to detect and treat those with subclinical atherosclerosis. Expand
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