interleukin-23 binding activity

Known as: IL-23, IL-23 binding, interleukin-23 binding 
Interacting selectively and non-covalently with interleukin-23. [GOC:jl]
National Institutes of Health

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4 relations
IL23A geneIL23A wt Alleleinterleukin-23

Broader (1)

interleukin-23 receptor activity

Papers overview

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Highly Cited
2011
Highly Cited
2011
The encephalitogenicity of TH17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
Interleukin 17 (IL-17)-producing helper T cells (TH17 cells) require exposure to IL-23 to become encephalitogenic, but the… (More)
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Highly Cited
2008
Highly Cited
2008
IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice.
RATIONALE The IL-23-IL-17A-producing CD4(+) T-cell (Th17 cell) axis plays an important role in the development of chronic… (More)
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Review
2008
Review
2008
IL-23 and IL-17 in tuberculosis.
Tuberculosis is a chronic disease requiring the constant expression of cellular immunity to limit bacterial growth. The constant… (More)
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Highly Cited
2007
Highly Cited
2007
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Psoriasis is a chronic inflammatory skin disease characterized by hyperplasia of the epidermis (acanthosis), infiltration of… (More)
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Highly Cited
2007
Highly Cited
2007
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
After activation, CD4+ helper T (TH) cells differentiate into distinct effector subsets that are characterized by their unique… (More)
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Highly Cited
2006
Highly Cited
2006
STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice.
IL-23 is a heterodimeric cytokine composed of a p19 subunit and the p40 subunit of IL-12. IL-23 has proinflammatory activity… (More)
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Highly Cited
2006
Highly Cited
2006
Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody.
BACKGROUND Interleukin (IL)-12p70 and IL-23 are key T helper-1 (TH1) cytokines that drive the inflammation seen in numerous… (More)
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Highly Cited
2006
Highly Cited
2006
IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.
IL-23 is a heterodimeric cytokine comprising a p19 subunit associated with the IL-12/23p40 subunit. Like IL-12, IL-23 is… (More)
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Highly Cited
2004
Highly Cited
2004
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria.
Macrophages (Mphi) play a central role as effector cells in immunity to intracellular pathogens such as Mycobacterium… (More)
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Highly Cited
2003
Highly Cited
2003
Antitumor and antimetastatic activity of IL-23.
The structure and T cell stimulatory effects of the recently discovered cytokine IL-23 are similar to, but distinct from, those… (More)
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