Genetic adaptation by Pseudomonas aeruginosa to the airways of cystic fibrosis patients.
- E. Smith, D. Buckley, M. Olson
- Biology, MedicineProceedings of the National Academy of Sciences…
- 30 May 2006
It is found that virulence factors that are required for the initiation of acute infections are often selected against during chronic infections, including cystic fibrosis patient's P. aeruginosa strains.
Salmonellae interplay with host cells
This Review focuses on the molecular mechanisms of these host–pathogen interactions, in terms of their context, significance and future perspectives.
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf
It is shown here that cytosolic bacterial flagellin activated caspase-1 through Ipaf but was independent of Toll-like receptor 5, a known flageLLin sensor, which raises the possibility that the salmonella pathogenicity island 1 type III secretion system cannot completely exclude 'promiscuous' secretion of flagella.
Recognition of Antimicrobial Peptides by a Bacterial Sensor Kinase
Human Toll-like receptor 4 recognizes host-specific LPS modifications
- A. Hajjar, R. Ernst, J. Tsai, Christopher B Wilson, Samuel I. Miller
- BiologyNature Immunology
- 25 March 2002
It is shown that human, but not murine, TLR4–MD-2 recognizes this adaptation and transmits robust proinflammatory signals in response to hexa-acylated but not penta-ACYlated LPS from P. aeruginosa.
Aminoglycoside antibiotics induce bacterial biofilm formation
- L. Hoffman, D. D'Argenio, M. MacCoss, Zhaoying Zhang, Roger A. Jones, Samuel I. Miller
- 25 August 2005
It is shown that subinhibitory concentrations of aminoglycoside antibiotics induce biofilm formation in P. aeruginosa and Escherichia coli, and the molecular basis of this response includes alterations in the level of c-di-GMP.
Variation in lipid A structure in the pathogenic yersiniae
- R. Rebeil, R. Ernst, B. Gowen, Samuel I. Miller, B. J. Hinnebusch
- BiologyMolecular Microbiology
- 1 June 2004
The results suggest that the production of a less immunostimulatory form of LPS upon entry into the mammalian host is a conserved pathogenesis mechanism in the genus Yersinia, and that species‐specific lipid A forms may be important for life cycle and pathogenicity differences.
LPS, TLR4 and infectious disease diversity
The hypothesis that the variability of bacterial ligands such as LPS and their innate immune receptors is an important factor in determining the outcome of infectious disease is examined.
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS
It is shown that a surface type II β-turn in the Escherichia coli protein EscU undergoes auto-cleavage by a mechanism involving cyclization of a strictly conserved asparagine residue in order to promote a secretion-competent state.