Kourosh Beroukhim

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INTRODUCTION Interleukin-17 inhibitors are the newest class of monoclonal antibodies approved by the US Food and Drug Administration for the treatment of psoriasis. Preclinical and Phase II studies of ixekizumab, a high-affinity anti-IL-17A monoclonal antibody, have proved promising. METHODS We conducted an extensive literature search using the PubMed(More)
INTRODUCTION A significant portion of patients with psoriasis have scalp and nail involvement. It has been reported that 40% to 45% of patients with psoriasis have nail psoriasis, and up to 80% have scalp involvement. Nail and scalp psoriasis have often been found to be difficult to treat, due to the poor penetration and poor compliance of topical(More)
BACKGROUND Studies investigating the molecular basis of psoriasis have established the central roles of TNFa, interleukin (IL)-12, IL-22 and IL-23, and now there is increasing evidence that IL-17 plays a vital role in the complex pathophysiology of this disease. Preclinical and phase II studies of medications targeting IL-17 and its receptor have thus far(More)
INTRODUCTION Interleukin (IL)-17 inhibitors are the most recent class of monoclonal antibodies approved by the FDA for psoriasis treatment. Preclinical and phase II studies of brodalumab, a high-affinity IL-17 receptor monoclonal antibody, have been encouraging. METHODS We conducted a literature search using the PubMed database in order to assess the(More)
On June 30th 2015, the FDA instituted a new system for the categorization of drug safety during pregnancy and lactation, known as the Pregnancy and Lactation Labeling Rule (PLLR), which replaces the "A, B, C, D, X" pregnancy labeling categories. The new rule will apply to all newly approved prescription medications, with a staggered phase-in for(More)
Department of Dermatology, University of California, San Francisco, CA, USA. Department of Medicine, University of Arizona, Tucson, AZ, USA. Department of Dermatology, Brigham and Women’s Hospital, Boston, MA, USA. David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Irvine School of Medicine, University of California, Irvine, CA, USA. Department(More)
INTRODUCTION Chronic skin conditions have been well reported to affect a patient's quality of life on multiple dimensions, including the psychosocial domain. Psychosocial is defined as the interrelation of social factors with an individual's thoughts and behavior. The assessment of the psychosocial impact of skin disease on a patient can help direct the(More)
Psoriasis is a complex chronic disease that can be challenging to manage, especially during pregnancy. The course of psoriasis can fluctuate throughout pregnancy as hormone levels change. In the only prospective study of pregnant patients with psoriasis, it was found that 55% of the patients reported improvement during pregnancy, 21% reported no change, and(More)