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IL23A wt Allele

Known as: Interleukin-Six, G-CSF Related Factor Gene, SGRF, IL-23 
Human IL23A wild-type allele is located in the vicinity of 12q13.2 and is approximately 2 kb in length. This allele, which encodes interleukin-23… 
National Institutes of Health

Related topics

Related topics

11 relations
12q13Cell Proliferation Regulatory ProcessCytokine Receptor BindingCytokine Signaling

Broader (1)

IL23A gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Autocrine IL-17A–IL-17RC neutrophil activation in fungal infections is regulated by IL-6, IL-23, RORγt and Dectin-2
Here we identified a population of bone marrow neutrophils that constitutively expressed the transcription factor RORγt and… 
Review
2013
Review
2013
Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and… 
Highly Cited
2011
Highly Cited
2011
Increased serum IL-17 and IL-23 in the patient with ankylosing spondylitis
Interleukin 17 (IL-17) is a Th17 cytokine associated with inflammation, autoimmunity, and defense against some bacteria; it has… 
Highly Cited
2009
Highly Cited
2009
CCR6 is required for IL-23-induced psoriasis-like inflammation in mice.
Psoriasis is a common immune-mediated chronic inflammatory skin disorder, but the mechanisms of pathogenesis are still poorly… 
Highly Cited
2009
Highly Cited
2009
Association of Inflammation-Related and microRNA Gene Expression with Cancer-Specific Mortality of Colon Adenocarcinoma
Purpose: Inflammatory genes and microRNAs have roles in colon carcinogenesis; therefore, they may provide useful biomarkers for… 
Highly Cited
2008
Highly Cited
2008
Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion.
Microenvironment molecular cues direct T helper (Th) cell differentiation; however, Th17 fate determination is still imprecisely… 
Highly Cited
2008
Highly Cited
2008
Molecular Mechanisms of Cytokine and Chemokine Release from Eosinophils Activated by IL-17A, IL-17F, and IL-23: Implication for Th17 Lymphocytes-Mediated Allergic Inflammation
IL-17A and IL-17F are members of the IL-17 family that play crucial roles in allergic inflammation. Recent studies reported that… 
Highly Cited
2007
Highly Cited
2007
IL-23 Is Critical in the Induction but Not in the Effector Phase of Experimental Autoimmune Encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE), a T cell-mediated inflammatory disease of the CNS, is a rodent model of human… 
Highly Cited
2006
Highly Cited
2006
Divergent effects of IL‐12 and IL‐23 on the production of IL‐17 by human T cells
IL‐23 is regarded as a major pro‐inflammatory mediator in autoimmune disease, a role which until recently was ascribed to its… 
Highly Cited
2006
Highly Cited
2006
Two-Sided Roles of IL-27: Induction of Th1 Differentiation on Naive CD4+ T Cells versus Suppression of Proinflammatory Cytokine Production Including IL-23-Induced IL-17 on Activated CD4+ T Cells…
Recent lines of evidence have demonstrated that IL-27, a newly identified IL-12-related cytokine, has two apparently conflicting… 
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