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Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severe COVID-19 patients
TLDR
The results demonstrate that excessive non-effective host immune responses by pathogenic T cells and inflammatory monocytes may associate with severe lung pathology and suggest that monoclonal antibodies targeting GM-CSF or interleukin 6 may be effective in blocking inflammatory storms and, therefore, be a promising treatment of severe COVID-19 patients. Expand
Liver-resident NK cells confer adaptive immunity in skin-contact inflammation.
TLDR
The findings of liver-resident NK cells shed new light on the acquisition of memory-like properties of NK cells and their roles in mediating CHS. Expand
Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells
TLDR
It is determined that liver trNK cells form a distinct lineage from cNK and thymic NK cells, which means that there are at least four distinct lineages of NK cells: cNK,Thymic, liver (and skin) trNK, and uterine tr NK cells. Expand
Functional exhaustion of antiviral lymphocytes in COVID-19 patients
TLDR
It is shown that the functional exhaustion of cytotoxic lymphocytes is associated with SRAS-CoV-2 infection, which may break down antiviral immunity at an early stage, and the role of NKG2A has been identified to induce NK cell exhaustion in chronic viral infections. Expand
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
TLDR
π-3 FAs prevented NLRP3 inflammasome-dependent inflammation and metabolic disorder in a high-fat-diet-induced type 2 diabetes model and suggest the potential clinical use of ω-3 FAs in gout, autoinflammatory syndromes, or other NLRP-driven inflammatory diseases. Expand
Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners.
TLDR
It is suggested that natural killer cells kill activated hepatic stellate cells via retinoic acid early inducible 1/NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent mechanisms, thereby ameliorating liver fibrosis. Expand
Liver: An organ with predominant innate immunity
TLDR
The liver is an organ with predominant innate immunity, playing an important role not only in host defenses against invading microorganisms and tumor transformation but also in liver injury and repair. Expand
NK cell-based immunotherapy for malignant diseases
TLDR
Several different approaches to NK-based immunotherapy, such as tissue-specific NK cells, killer receptor-oriented NK cells and chemically treated NK cells are discussed, and a list of NK cell therapies to treat several types of cancer in clinical trials is reviewed here. Expand
Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome
TLDR
DA and DRD1 signaling prevent NLRP3 inflammasome-dependent inflammation, including neurotoxin-induced neuroinflammation, LPS-induced systemic inflammation, and monosodium urate crystal (MSU)-induced peritoneal inflammation. Expand
Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS.
TLDR
It is suggested that STAT1 plays a harmful role in Con A-mediated hepatitis by activation of CD4(+) and NK T cells and directly inducing hepatocyte death, whereas STAT3 protects against liver injury by suppression of IFN-gamma signaling and induction of antiapoptotic protein Bcl-X(L). Expand
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