interleukin-21

Known as: Za11, IL21, IL-21 
Interleukin-21 (155 aa, ~18 kDa) is encoded by the human IL21 gene. This protein plays a role in both receptor-mediated signaling and the… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
CD4+ and CD8+ T cell functions are rapidly aborted during chronic infection, preventing viral clearance. CD4+ T cell help is… (More)
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Highly Cited
2008
Highly Cited
2008
T cell help to B cells is a fundamental property of adaptive immunity, yet only recently have many of the cellular and molecular… (More)
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Review
2008
Review
2008
Interleukin-21 (IL-21), a potent immunomodulatory four-alpha-helical-bundle type I cytokine, is produced by NKT and CD4(+) T… (More)
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Highly Cited
2008
Highly Cited
2008
After activation, CD4(+) helper T (Th) cells differentiate into distinct effector subsets. Although chemokine (C-X-C motif… (More)
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Highly Cited
2007
Highly Cited
2007
On activation, naive T cells differentiate into effector T-cell subsets with specific cytokine phenotypes and specialized… (More)
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Highly Cited
2007
Highly Cited
2007
T helper cells that produce interleukin 17 (IL-17; 'TH-17 cells') are a distinct subset of proinflammatory cells whose in vivo… (More)
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Highly Cited
2007
Highly Cited
2007
After activation, CD4+ helper T (TH) cells differentiate into distinct effector subsets that are characterized by their unique… (More)
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Highly Cited
2005
Highly Cited
2005
Interleukin (IL)-21 is the most recently recognized of the cytokines that share the common cytokine receptor gamma chain (gamma(c… (More)
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Highly Cited
2003
Highly Cited
2003
Interleukin 21 (IL-21) is a newly described cytokine with homology to IL-4 and IL-15. They belong to a cytokine family that uses… (More)
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Highly Cited
2000
Highly Cited
2000
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here… (More)
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