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interleukin-21

Known as: Za11, IL21, IL-21 
Interleukin-21 (155 aa, ~18 kDa) is encoded by the human IL21 gene. This protein plays a role in both receptor-mediated signaling and the… 
National Institutes of Health

Related topics

Related topics

20 relations
Cell Proliferation Regulatory ProcessCell-Mediated CytolysisCytokine GeneCytokine Receptor Binding

Broader (2)

IL21 wt AlleleInterleukins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Gene–Gene and Gene-Sex Epistatic Interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in Systemic Lupus Erythematosus
Several confirmed genetic susceptibility loci involved in the interferon signaling and Th17/B cell response for SLE in Chinese… 
2011
2011
Expression of miRNAs miR-133b and miR-206 in the Il17a/f Locus Is Co-Regulated with IL-17 Production in αβ and γδ T Cells
Differentiation of T helper 17 cells (Th17) is a multistep process that involves the cytokines IL-6, TGF-β, and IL-23 as well as… 
2011
2011
Exposure to IL-15 and IL-21 Enables Autoreactive CD8 T Cells To Respond to Weak Antigens and Cause Disease in a Mouse Model of Autoimmune Diabetes
Autoreactive CD8+ T lymphocytes play a key role in the pathogenesis of several autoimmune diseases. It is not yet well understood… 
Highly Cited
2010
Highly Cited
2010
Combination of IL-21 and IL-15 enhances tumour-specific cytotoxicity and cytokine production of TCR-transduced primary T cells
IL-21, and to a lesser extent IL-15, inhibits differentiation of antigen-primed CD8 T cells and promotes their homeostasis and… 
Highly Cited
2010
Highly Cited
2010
Critical role for IL‐21 in both primary and memory anti‐viral CD8+ T‐cell responses
While it is well established that CD8+ T cells generated in the absence of CD4+ T cells mediate defective recall responses, the… 
Highly Cited
2010
Highly Cited
2010
An optimized assay for the enumeration of antigen-specific memory B cells in different compartments of the human body.
Review
2010
Review
2010
Interleukin-21 triggers effector cell responses in the gut.
In the gut of patients with Crohn's disease and patients with ulcerative colitis, the major forms of inflammatory bowel diseases… 
Highly Cited
2009
Highly Cited
2009
Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus
IL-2 and IL-21 are two cytokines with great potential to affect autoimmune infiltration of nonlymphoid tissue, and are contained… 
2006
2006
Polychromatic flow cytometry: A rapid method for the reduction and analysis of complex multiparameter data
Recent advances in flow cytometry have resulted in the development of reliable techniques for performing polychromatic (5–17… 
2006
2006
IL-21 Enhances Tumor-Specific CTL Induction by Anti-DR5 Antibody Therapy1
Tumor cell apoptosis is the basis of many cancer therapies, and tumor-specific T cells are the principal effectors of successful… 
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