Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.

  title={Loss of parity between IL-2 and IL-21 in the NOD Idd3 locus.},
  author={Helen M McGuire and Alexis Vogelzang and Natasha Hill and Malin Flodstr{\"o}m-Tullberg and Jonathan Sprent and C Christopher King},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 46},
IL-2 and IL-21 are two cytokines with great potential to affect autoimmune infiltration of nonlymphoid tissue, and are contained within the strongest non-MHC-linked locus for type 1 diabetes (T1D) susceptibility on the nonobese diabetic (NOD) mouse (Idd3). IL-21 is necessary for the development of diabetes in the NOD mouse, but a number of important studies argue that decreased expression of IL-2 explains Idd3. In this study, we demonstrate that the amount of IL-21, but not IL-2, correlated… CONTINUE READING


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IL-21 is required for the development of type 1 diabetes in NOD mice

  • AP Sutherland
  • Diabetes
  • 2009

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