interleukin-2 receptor beta

Known as: IL 2 15 Receptor beta, Interleukin-2, 15 Receptor beta Subunit, IL 2Rbeta2 
A receptor subunit that is a shared component of the INTERLEUKIN 2 RECEPTOR and the INTERLEUKIN-15 RECEPTOR. High affinity receptor complexes are… (More)
National Institutes of Health

Related topics

Related topics

12 relations

Broader (1)

CD122 Antigens

Narrower (2)

IL2RB protein, humanIl2rb protein, mouse
IL2RB wt AlleleIn BloodProcess of secretionagonists
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Papers overview

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2001
2001
Defective expression of the interleukin-2/interleukin-15 receptor beta subunit leads to a natural killer cell-deficient form of severe combined immunodeficiency.
Development of T and natural killer (NK) cells is critically dependent on cytokine signaling, and defects in cytokine receptor… (More)
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2001
2001
Involvement of the ubiquitin/proteasome system in sorting of the interleukin 2 receptor beta chain to late endocytic compartments.
Down-regulation of cell surface growth factor receptors plays a key role in the tight control of cellular responses. Recent… (More)
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Highly Cited
1995
Highly Cited
1995
Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.
In mice lacking the interleukin-2 receptor beta chain (IL-2R beta), T cells were shown to be spontaneously activated, resulting… (More)
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1995
1995
Signaling through the interleukin 2 receptor beta chain activates a STAT-5-like DNA-binding activity.
To explore the possible involvement of STAT factors ("signal transducers and activators of transcription") in the interleukin 2… (More)
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1995
1995
Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.
The high-affinity interleukin 2 (IL-2) receptor (IL-2R) consists of three subunits: the IL-2R alpha, IL-2R beta c, and IL-2R… (More)
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Highly Cited
1994
Highly Cited
1994
Cytoplasmic domains of the interleukin-2 receptor beta and gamma chains mediate the signal for T-cell proliferation.
The interleukin-2 receptor (IL-2R) consists of three distinct chains (alpha, beta, gamma) which bind IL-2 and generate a… (More)
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Highly Cited
1994
Highly Cited
1994
Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
Interleukin-2 (IL-2) signaling requires the dimerization of the IL-2 receptor beta.(IL-2R beta) and common gamma (gamma c) chains… (More)
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Highly Cited
1993
Highly Cited
1993
Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice
The interleukin 2 receptor beta chain (IL-2R beta) is preferentially expressed in natural killer (NK) cells, but is not detected… (More)
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Highly Cited
1989
Highly Cited
1989
A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain.
Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to… (More)
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1989
1989
Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.
The human high-affinity receptor for interleukin 2 (IL-2) has been proposed as being a membrane complex composed of at least two… (More)
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