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Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.
Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 [HHV-8]) is a herpesvirus linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma, and a… Expand
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function.
Delta-like 4 (Dll4), a membrane-bound ligand for Notch1 and Notch4, is selectively expressed in the developing endothelium and in some tumor endothelium, and it is induced by vascular endothelial… Expand
Human interferon-inducible protein 10 is a potent inhibitor of angiogenesis in vivo
- A. Angiolillo, C. Sgadari, +6 authors G. Tosato
- Biology, Medicine
- The Journal of experimental medicine
- 1 July 1995
Human interferon-inducible protein 10 (IP-10), a member of the alpha chemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes… Expand
Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma.
Despite some exciting new leads in molecular pathogenesis, AIDS-defining primary effusion lymphoma (PEL) remains a fatal malignancy. The lack of substantial progress in the management of PEL demands… Expand
Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1.
- O. Salvucci, L. Yao, S. Villalba, Agatha Sajewicz, S. Pittaluga, G. Tosato
- Biology, Medicine
- 15 April 2002
The chemokine stromal-derived factor-1 (SDF-1) and its unique receptor, CXCR4, are required for normal cardiovascular development, but a critical role for SDF-1 in postnatal vascular remodeling and… Expand
Differential processing of stromal-derived factor-1α and stromal-derived factor-1β explains functional diversity
The chemokine stromal-derived factor-1 (SDF-1), which is constitutively expressed in most tissues as SDF-1α and SDF-1β resulting from alternative gene splicing, regulates hematopoiesis, lymphocyte… Expand
Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2.
Neuropilin-1 (NRP-1) is a type 1 membrane protein that binds the axon guidance factors belonging to the class-3 semaforin family. In endothelial cells, NRP-1 serves as a co-receptor for vascular… Expand
Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection.
Clinical, serologic, virologic, and immunologic evaluations for 31 adults with chronic illness and fatigue suggested that 23 had persisting Epstein-Barr virus infection. Among these 23 patients,… Expand
IL-10 inhibits human T cell proliferation and IL-2 production.
Human IL-10 has been reported previously to inhibit the secretion of IFN-gamma in PBMC. In this study, we have found that human IL-10 inhibits T cell proliferation to either mitogen or anti-CD3 mAb… Expand
Inhibition of angiogenesis by interleukin-12 is mediated by the interferon-inducible protein 10.
Interleukin 12 (IL-12), a multifunctional cytokine produced by macrophages and B-cell lines, induces interferon-gamma (IFN-gamma) production, stimulates growth of both T and natural killer cells,… Expand