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insulin receptor substrate 4 protein

Known as: Insulin Receptor Substrate-4, Insulin Receptor Substrate-4 Protein, Insulin Receptor Substrate 4 
Similar in function to IRS1 and IRS2; insulin receptor substrate 4 is a cytoplasmic protein that contains many potential tyrosine and serine… 
National Institutes of Health

Related topics

Related topics

9 relations
Adaptor Proteins, Signal TransducingAdaptor Signaling Protein GeneIRS4 geneLigand Binding

Narrower (1)

IRS4 wt Allele

Broader (1)

Insulin Receptor Substrate Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Abstract P3-05-13: Overexpression of insulin receptor substrate 4 can mediate acquired resistance to lapatinib-containing regimens in HER2+ breast cancer cells
Background: The HER2 pathway can be inhibited by potent targeting agents such as lapatinib (L), trastuzumab (T), or their… 
2014
2014
Proliferation and migration of hepatoblastoma cells are mediated by IRS-4 via PI3K/Akt pathways.
Levels of IRS-4 (insulin receptor substrate-4) in hepatoblastoma cells from the patients, HepG2 and HuH-6 cell lines were… 
2013
2013
[Effects of peroxisome proliferator-activated receptors γ on the expression of insulin receptor substrate-4 gene in rat cortical neurons and mouse brain].
OBJECTIVE To investigate the effect of peroxisome proliferator-activated receptors γ (PPARγ) on insulin receptor substrate-4 (IRS… 
2013
2013
Case report of a patient with schizophrenia and a mutation in the insulin receptor substrate-4 gene.
This report deals with a female patient with schizophrenia who was found to have a mutation in the insulin receptor substrate-4… 
2012
2012
A BRET assay for monitoring insulin receptor interactions and ligand pharmacology
The insulin receptor (IR) belongs to the receptor tyrosine kinase super family and plays an important role in glucose homeostasis… 
2011
2011
The insulin receptor substrate-4 (IRS-4) gene and schizophrenia: no evidence for a main genetic factor, however one report of a single schizophrenia patient with a mutation.
OBJECTIVES Since there are clear indications that schizophrenia is a systemic disorder, we sought for a common molecular basis… 
2011
2011
Improving single-channel methods for land surface temperature retrieval from HJ-1B IRS4
  • G. Wen
  • 2011
  • Corpus ID: 129987462
In this paper,we present a modification of the Jimenez-Munoz and Sobrino(JMS) single-channel method for land surface temperature… 
2010
2010
Role of IRS-4 in PI3-K activation by insulin in HepG2 cells, modulation by Angiotensin II
2003
2003
Association study of insulin receptor substrate-4 gene polymorphism with type 2 diabetes
Objective To study the association of insulin receptor substrate-4 (IRS-4) gene codon 879 c/g polymorphism with type 2 diabetes… 
1998
1998
Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance
Summary The family of insulin receptor substrates (IRS1–4) is defined by proteins with an overall similar structure. IRS-1 and… 
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