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IRS4 gene

Known as: Insulin Receptor Substrate 4 Gene, PY160, INSULIN RECEPTOR SUBSTRATE 4 
This gene plays a role in signal transduction and ligand binding.
National Institutes of Health

Related topics

Related topics

4 relations
Ligand BindingSignal Transductioninsulin receptor substrate 4 proteinprotein protein interaction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Targeting oncogenic receptor, currently the standard of care
In 1989 91,George Zhu[1] first postulate oncogenic receptor (Voice of America, 1992, 12:31; Curr Pharm Biotechnol, 2013, 14:859… 
2014
2014
Proliferation and migration of hepatoblastoma cells are mediated by IRS-4 via PI3K/Akt pathways.
Levels of IRS-4 (insulin receptor substrate-4) in hepatoblastoma cells from the patients, HepG2 and HuH-6 cell lines were… 
2012
2012
Optimisation of Downscaled Tandem Affinity Purifications to Identify Core Protein Complexes.
In this study we show that via stable, retroviral-expression of tagged EGFR del (L747-S752 deletion mutant) in the PC9 lung… 
2012
2012
Simultaneous Translocation of Both TCR Loci (14q11) with Rare Partner Loci (Xq22 and 12p13) in a Case of T-lymphoblastic Leukemia
The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve… 
2006
2006
Angiotensin II modulates tyr-phosphorylation of IRS-4, an insulin receptor substrate, in rat liver membranes
Angiotensin II (Ang II), a major regulator of blood pressure, is also involved in the control of cellular proliferation and… 
2004
2004
Negative Regulation of Phosphatidylinositol 4,5-Bisphosphate Levels by the INP51-associated Proteins TAX4 and IRS4*
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) is an important second messenger in signaling pathways in organisms ranging… 
2003
2003
Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.
Insulin receptor substrate (IRS) proteins represent key elements of the insulin-signaling cascade. IRS-4 is the most recently… 
Highly Cited
2002
Highly Cited
2002
Hepatocyte growth factor stimulates proliferation of pancreatic beta-cells particularly in the presence of subphysiological glucose concentrations.
We investigated the role of hepatocyte growth factor (HGF) in beta-cell growth and its complex intracellular signal transduction… 
1999
1999
Insulin receptor substrate 4 supports insulin- and interleukin 4-stimulated proliferation of hematopoietic cells.
Signaling from the activated insulin receptor is initiated by its tyrosine phosphorylation of the insulin receptor substrates… 
1998
1998
Common amino acid substitutions in insulin receptor substrate-4 are not associated with Type II diabetes mellitus or insulin resistance
Summary The family of insulin receptor substrates (IRS1–4) is defined by proteins with an overall similar structure. IRS-1 and… 
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