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High‐fat Diets: Modeling the Metabolic Disorders of Human Obesity in Rodents
In this review, metabolic data obtained with different HF diet approaches are compiled and whole‐body and organ‐specific diet effects are analyzed. Expand
Defining high-fat-diet rat models: metabolic and molecular effects of different fat types.
High-fat (HF)-diet rodent models show an intact transcriptional hepatic insulin effect despite resistance to insulin's metabolic actions, and diets based on LC-SFA and MUFA induced hepatic steatosis with SREBP1c activation. Expand
A review of activity indices and efficacy end points for clinical trials of medical therapy in adults with ulcerative colitis.
The task force met initially in person for discussion and summarized in a draft manuscript by the primary authors and discussed at the annual IOIBD meetings in 2004 and 2005. Expand
Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation.
Findings indicate a major role of monocyte/macrophage dysfunction in the pathophysiology of GvHD and strongly suggest a future risk assessment or even donor selection through NOD2/CARD15 typing. Expand
Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients.
Clinical and immunogenetic findings as well as similarities and overlapping clinical symptoms with other autoimmune or rheumatic diseases suggest that immunological mechanisms play a major role in the pathogenesis of relapsing polychondritis. Expand
A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease.
This work aims to provide a database of clinical trials conducted in patients with Crohn’s and Colitis over a 12-month period and to establish a baseline for evaluating the safety and effectiveness of these studies. Expand
Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.
Omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease. Expand
Systemic chemerin is related to inflammation rather than obesity in type 2 diabetes
Background  The adipokine chemerin modulates the function of innate immune cells and may link obesity and inflammation, and therefore, a possible relation of chemerin to inflammatory proteins inExpand
Comparison of magnetic resonance imaging colonography with conventional colonoscopy for the assessment of intestinal inflammation in patients with inflammatory bowel disease: a feasibility study
MRI based colonography is not suitable for adequately assessing the extent of colonic inflammation in patients with IBD, and only severe colonicinflammation in patientsWith CD can be sufficiently visualised, and virtual endoscopy did not add any relevant information. Expand