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TOR Signaling in Growth and Metabolism
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Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.
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Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.
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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
TLDR
Two distinct TOR complexes constitute a primordial signalling network conserved in eukaryotic evolution to control the fundamental process of cell growth.
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The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
TLDR
The rapamycin-sensitive TOR signalling pathway in Saccharomyces cerevisiae activates a cell-growth program in response to nutrients such as nitrogen and carbon and broadly controls nutrient metabolism by sequestering several transcription factors in the cytoplasm.
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Target of Rapamycin (TOR) in Nutrient Signaling and Growth Control
TLDR
The yeast Saccharomyces cerevisiae has played a prominent role in both the discovery of TOR and the elucidation of its function, and the TOR signaling network in S. cerevisia is reviewed.
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TOR, a Central Controller of Cell Growth
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TOR Regulates Ribosomal Protein Gene Expression via PKA and the Forkhead Transcription Factor FHL1
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TOR controls translation initiation and early G1 progression in yeast.
TLDR
It is proposed that the TORs, two related phosphatidylinositol kinase homologues, are part of a novel signaling pathway that activates eIF-4E-dependent protein synthesis and, thereby, G1 progression in response to nutrient availability and may constitute a checkpoint that prevents early G 1 progression and growth in the absence of nutrients.
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Making new contacts: the mTOR network in metabolism and signalling crosstalk
TLDR
Emerging evidence provides new insight into the control of mTOR by other pathways such as Hippo, WNT and Notch signalling, and this progress has expanded the list of downstream effectors and upstream regulators of m TOR signalling.
View on Nature
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