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immunotoxin LMB-7

Known as: HB21(Fv)PE40, LMB-7, LMB-7 immunotoxin 
A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin… 
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisPeptide Elongation Factor 2Translational Repressionmitochondrial toxicity

Broader (2)

ExotoxinsMonoclonal Antibodies

Papers overview

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2004
2004
Effects of BCL-2 overexpression on the sensitivity of MCF-7 breast cancer cells to ricin, diphtheria and Pseudomonas toxin and immunotoxins
Immunotoxins are presently being evaluated as novel agents for cancer therapy. The direct mechanism by which immunotoxins kill… 
2000
2000
Site-specific expression of transferrin receptor by human colon cancer cells directly correlates with eradication by antitransferrin recombinant immunotoxin.
We determined the efficacy of HB21(Fv)PE40, a single-chain immunotoxin made by fusing the variable regions of a monoclonal… 
Highly Cited
2000
Highly Cited
2000
Cortical cholinergic inputs mediate processing capacity: effects of 192 IgG‐saporin‐induced lesions on olfactory span performance
An olfactory span task that required rats to discriminate an olfactory stimulus added to an increasing list of such stimuli… 
Highly Cited
1999
Highly Cited
1999
Regional treatment of epidermal growth factor receptor vIII-expressing neoplastic meningitis with a single-chain immunotoxin, MR-1.
The incidence of neoplastic meningitis is on the rise. Neoplastic meningitis can result from a direct seeding of the neuraxis by… 
Highly Cited
1998
Highly Cited
1998
Role of caspases in immunotoxin-induced apoptosis of cancer cells.
Immunotoxins composed of antibodies linked to plant or bacterial toxins are being evaluated in the treatment of cancer. It is… 
1997
1997
Identification of epitopes on a mutant form of Pseudomonas exotoxin using serum from humans treated with Pseudomonas exotoxin containing immunotoxins
PE38 is a 38‐kDa derivative of the 66‐kDa Pseudomonas exotoxin (PE) in which the cell binding domain of PE (domain Ia, amino… 
1996
1996
Intraseptal injection of the cholinergic immunotoxin 192-IgG saporin fails to disrupt latent inhibition in a conditioned taste aversion paradigm
Highly Cited
1994
Highly Cited
1994
Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
Disulfide-stabilized Fvs (dsFv) are recombinant Fv fragments of antibodies in which the inherently unstable VH-VL heterodimer is… 
1994
1994
Mutations of two lysine residues in the CDR loops of a recombinant immunotoxin that reduce its sensitivity to chemical derivatization.
B3(Fv)-PE38 is a recombinant single-chain immunotoxin in which the Fv region of monoclonal antibody B3 is connected to a… 
1992
1992
Immunological properties of ribosome-inactivating proteins and a saporin immunotoxin.
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