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immunotoxin HA22

Known as: HA22, MOXETUMOMAB PASUDOTOX 
A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody covalently fused to a 38 KDa fragment of Pseudomonas exotoxin-A… 
National Institutes of Health

Related topics

Related topics

10 relations
B-LymphocytesNCIt Antineoplastic Agent TerminologyPeptide Elongation Factor 2Positive Regulation of Apoptosis

Broader (2)

Bacterial ToxinsExotoxins

Narrower (1)

CAT-8015

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Phase I Study of the anti-CD22 immunotoxin moxetumomab pasudotox for childhood acute lymphoblastic leukemia.
Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia… 
Review
2016
Review
2016
New monoclonal antibodies for the treatment of acute lymphoblastic leukemia.
Review
2015
Review
2015
Immunoconjugates in the management of hairy cell leukemia.
2014
2014
Heterocyclic ring extension of androstenedione: Synthesis and cytotoxicity of fused pyran, pyrimidine and thiazole derivatives
2013
2013
Methylation of the DPH1 promoter causes immunotoxin resistance in acute lymphoblastic leukemia cell line KOPN-8.
Review
2013
Review
2013
Hairy Cell Leukemia—New Genes, New Targets
Hairy cell leukemia (HCL), a B cell malignancy comprising 2 % of all leukemias, has become quite exciting recently with regard to… 
2009
2009
Androgen metabolism and biotransformation in nontumoral and malignant human liver tissues and cells
Highly Cited
2007
Highly Cited
2007
Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts
Purpose: To determine the antitumor activity of the anti–mesothelin immunotoxin SS1P in combination with gemcitabine against… 
Highly Cited
2005
Highly Cited
2005
YC-1 [3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl Indazole] Exhibits a Novel Antiproliferative Effect and Arrests the Cell Cycle in G0-G1 in Human Hepatocellular Carcinoma Cells
This study delineates the antiproliferative activities and in vivo efficacy of YC-1 [3-(5′-hydroxymethyl-2′-furyl)-1-benzyl… 
Highly Cited
2004
Highly Cited
2004
Induction of caspase-dependent programmed cell death in B-cell chronic lymphocytic leukemia by anti-CD22 immunotoxins.
B cells of chronic lymphocytic leukemia (CLL) are long-lived in vivo, possibly because of defects in apoptosis. We investigated… 
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