immunotoxin HA22

Known as: HA22, MOXETUMOMAB PASUDOTOX 
A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody covalently fused to a 38 KDa fragment of Pseudomonas exotoxin-A… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
PURPOSE To conduct a phase I dose-escalation trial assessing safety and response of recombinant immunotoxin moxetumomab pasudotox… (More)
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Highly Cited
2012
Highly Cited
2012
Recombinant immunotoxins (RITs) are hybrid proteins used to treat cancer. These proteins are composed of an Fv that reacts with… (More)
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Review
2011
Review
2011
Recombinant immunotoxins are fusion proteins that contain the cytotoxic portion of a protein toxin fused to the Fv portion of an… (More)
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2011
2011
PURPOSE Sonic hedgehog (Shh) signaling is critical to embryogenesis and resistance to chemotherapy. We aimed to examine the role… (More)
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2010
2010
Acute lymphoblastic leukaemia (ALL) remains the most frequent cause of cancer-related mortality in paediatrics and outcome is… (More)
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Highly Cited
2010
Highly Cited
2010
MicroRNAs (miRNAs) play critical roles in embryonic development and are frequently deregulated in human cancers. The let-7 family… (More)
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Highly Cited
2009
Highly Cited
2009
Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an… (More)
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Highly Cited
2008
Highly Cited
2008
Recombinant immunotoxins are hybrid proteins composed of an Fv that binds to a tumor antigen fused to a bacterial or plant toxin… (More)
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2007
2007
PURPOSE To determine the antitumor activity of the anti-mesothelin immunotoxin SS1P in combination with gemcitabine against… (More)
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2005
2005
PURPOSE RFB4 (dsFv)-PE38 (BL22) is a recombinant immunotoxin containing an anti-CD22 (Fv) fused to truncated Pseudomonas exotoxin… (More)
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