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JAK-STAT Signaling: From Interferons to Cytokines*
TLDR
This research presents a new probabilistic approach to cell reprograming that allows us to assess the importance of immune checkpoints in the immune response to E.coli. Expand
Serine phosphorylation of STATs
TLDR
This review addresses recent advances in understanding the regulation of STAT serine phosphorylation, as well as the kinases and other signal transducers implied in this process. Expand
Type I interferon inhibits interleukin-1 production and inflammasome activation.
TLDR
Type I interferon inhibited interleukin-1 (IL-1) production through two distinct mechanisms, which may explain the effectiveness of type I IFN in the treatment of inflammatory diseases but also the observed "weakening" of the immune system after viral infection. Expand
The Yin and Yang of type I interferon activity in bacterial infection
TLDR
An increasing body of work shows that type I IFNs have an important role in the host response to bacterial infection, and can influence various immune effector mechanisms. Expand
Partial impairment of cytokine responses in Tyk2-deficient mice.
TLDR
Tyk2-/- mice are unable to clear vaccinia virus and show a reduced T cell response after LCMV challenge, which imply a selective contribution of Tyk2 to the signals triggered by various biological stimuli and cytokine receptors. Expand
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
TLDR
Ch Chromatin immunoprecipitation indicated that DDX3X is recruited to the IFN promoter upon infection with Listeria monocytogenes, suggesting a transcriptional mechanism of action. Expand
Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
TLDR
It is reported that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS, and IFN-β–null but not STAT1-null mice were also resistant to high dose LPS treatment, suggesting thatTyk2 and IFn-β are essential effectors in LPS induced lethality. Expand
Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-gamma.
TLDR
The results link the deactivating effect of chronic LPS exposure on macrophages with its ability to induce SOCS3 with the LPS-dependent reduction of IFN-gamma-mediated Janus kinase 1 (JAK1) activation. Expand
GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression.
TLDR
This review focuses on the identification and definition of GAS elements, their interaction with Stat transcription factors, and their contribution to the specificity of cytokine-induced gene expression. Expand
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB
TLDR
It is reported that nanomolar concentrations of gliotoxin inhibited the activation of transcription factor NF-kappaB in response to a variety of stimuli in T and B cells, raising the possibility that the immunosuppression observed during aspergillosis results in part from gliot toxin-mediated NF- kappaB inhibition. Expand
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