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imidazobenzodiazepine

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1981-2013
051019812013

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2014
2014
Alcohol Selectivity of β3-Containing GABAA Receptors: Evidence for a Unique Extracellular Alcohol/Imidazobenzodiazepine Ro15-4513 Binding Site at the α+β- Subunit Interface in αβ3δ GABAA Receptors
GABAA receptors (GABARs) have long been the focus for acute alcohol actions with evidence for behaviorally relevant low… (More)
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2006
2006
Low-dose alcohol actions on alpha4beta3delta GABAA receptors are reversed by the behavioral alcohol antagonist Ro15-4513.
Although it is now more than two decades since it was first reported that the imidazobenzodiazepine Ro15-4513 reverses behavioral… (More)
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2003
2003
Structural requirements for imidazobenzodiazepine binding to GABA(A) receptors.
Several structural subclasses of ligands bind to the benzodiazepine (BZD) binding site of the GABA(A) receptor. Previous studies… (More)
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2002
2002
Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513.
Ligands binding to the benzodiazepine-binding site in gamma-aminobutyric acid type A (GABA(A)) receptors may allosterically… (More)
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1996
1996
Synthesis and pharmacological properties of novel 8-substituted imidazobenzodiazepines: high-affinity, selective probes for alpha 5-containing GABAA receptors.
The synthesis and pharmacological properties of imidazobenzodiazepines with both high affinity and selectivity for alpha 5… (More)
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Highly Cited
1996
Highly Cited
1996
Pharmacological modulation of the diazepam-insensitive recombinant gamma-aminobutyric acidA receptors alpha 4 beta 2 gamma 2 and alpha 6 beta 2 gamma 2.
We characterized modulation of the gamma-aminobutyric acid (GABA)-evoked responses of the diazepam-insensitive alpha 4 beta 2… (More)
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1991
1991
Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure.
BACKGROUND Increased gamma-aminobutyric acid (GABA) neurotransmission has been implicated in the pathogenesis of hepatic… (More)
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1988
1988
Effects of Ro15-4513 and other benzodiazepine receptor inverse agonists on alcohol-induced intoxication in the rat.
The ability of the imidazobenzodiazepine Ro15-4513 to antagonize the behavioral intoxication produced by ethanol and related… (More)
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1987
1987
Effect of an imidazobenzodiazepine, Ro15-4513, on the incoordination and hypothermia produced by ethanol and pentobarbital.
The imidazobenzodiazepine, Ro15-4513, which is a partial inverse agonist at brain benzodiazepine receptors, reversed the… (More)
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Highly Cited
1986
Highly Cited
1986
A selective imidazobenzodiazepine antagonist of ethanol in the rat.
Ethanol, at pharmacologically relevant concentrations of 20 to 100 mM, stimulates gamma-aminobutyric (GABA) receptor-mediated… (More)
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