Drug interactions at GABAA receptors
- E. Korpi, G. Gründer, H. Lüddens
- BiologyProgress in neurobiology
- 1 June 2002
Attenuated sensitivity to neuroactive steroids in gamma-aminobutyrate type A receptor delta subunit knockout mice.
- R. Mihalek, P. Banerjee, G. Homanics
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 26 October 1999
The results begin to illuminate the novel contributions of the delta subunit to GABA pharmacology and sedative/hypnotic responses and behavior and provide insights into the physiology of neurosteroids.
Modifying the Subunit Composition of TASK Channels Alters the Modulation of a Leak Conductance in Cerebellar Granule Neurons
- M. Aller, E. Veale, S. Brickley
- BiologyJournal of Neuroscience
- 7 December 2005
It is demonstrated that TASK-1 channels contribute to the properties of IK(SO) in adult CGNs, however, TAS k2P channel subunit composition does not alter the resting excitability of C GNs but does influence sensitivity to endogenous modulators such as Zn2+ and H+.
Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.
- G. Homanics, T. Delorey, R. Olsen
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 1997
Hyperactivity, lack of coordination, and seizures in beta3-deficient mice are consistent with reduced presynaptic inhibition in spinal cord and impaired inhibition in higher cortical centers and/or pleiotropic developmental defects.
Ligand-Gated Ion Channel Subunit Partnerships: GABAAReceptor α6 Subunit Gene Inactivation Inhibits δ Subunit Expression
Removal of intact α6 protein from cerebellar granule cells allowed perturbations in other subunit levels to be studied and provided genetic evidence for a specific association between the α6 and δ subunits.
Drug interactions at GABA(A) receptors.
- E. Korpi, G. Gründer, H. Lüddens
- BiologyProgress in neurobiology
- 2002
The data indicate that the present ligands are only partly satisfactory tools and further ligands with subtype-selective properties are needed for imaging purposes and for confirming the behavioral and functional results of the studies presently carried out in gene-targeted mice with other species, including man.
Long-term cognitive and neurochemical effects of “bath salt” designer drugs methylone and mephedrone
- Bjørnar den Hollander, S. Rozov, A. Linden, M. Uusi-Oukari, I. Ojanperä, E. Korpi
- Biology, PsychologyPharmacology, Biochemistry and Behavior
- 31 January 2013
Benzodiazepine-induced motor impairment linked to point mutation in cerebeilar GABAA receptor
- E. Korpi, C. Kleingoor, H. Kettenmann, P. Seeburg
- Biology, PsychologyNature
- 28 January 1993
The ct6 gene of ANT rats is expressed at wild-type levels but carries a point mutation generating an arginine-to-glutamine substitution at position 100, which suggests that cerebeilar motor control may be a distinct behavioural correlate of the a6-subunit-containing GABAA receptor subtype.
Regulation of GABAA Receptor Subunit Expression by Pharmacological Agents
- M. Uusi-Oukari, E. Korpi
- Biology, MedicinePharmacological Reviews
- 1 March 2010
Drug development for neuropsychiatric disorders, including epilepsy, alcoholism, schizophrenia, and anxiety, has been ongoing for several years and one key step to extend drug development related to GABAA receptors is likely to require deeper understanding of the adaptational mechanisms of neurons, receptors themselves with interacting proteins, and finally receptor subunits during drug action and in neuropsychiatrics disease processes.
Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior
- G. Homanics, T. Delorey, R. Olsen
- Biology, Psychology
- 15 April 1997
Hyperactivity, lack of coordination, and seizures in β3-deficient mice are consistent with reduced presynaptic inhibition in spinal cord and impaired inhibition in higher cortical centers and/or pleiotropic developmental defects.
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