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Developmental and regional expression in the rat brain and functional properties of four NMDA receptors
Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.
The yeast two-hybrid system was used to show that the cytoplasmic tails of NMDA receptor subunits interact with a prominent postsynaptic density protein PSD-95, which may affect the plasticity of excitatory synapses.
Heteromeric NMDA Receptors: Molecular and Functional Distinction of Subtypes
Molecular cloning identified three complementary DNA species of rat brain, encoding NMDA receptor subunits NMDAR2A (NR2A), NR2B, and NR2C, which are 55 to 70% ientical in sequence, and these are structurally related, with less than 20% sequence identity, to other excitatory amino acid receptor sub Units.
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2
It is concluded that this transcript is the physiologically most important substrate of ADAR2, as it specifies an ion channel determinant, the Q/R site, in AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) receptor GluR-B pre-messenger RNA.
Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close…
Importance of AMPA receptors for hippocampal synaptic plasticity but not for spatial learning.
The results suggest that CA1 hippocampal LTP is controlled by the number or subunit composition of AMPA receptors and show a dichotomy between LTP in CA1 and acquisition of spatial memory.
A molecular determinant for submillisecond desensitization in glutamate receptors.
- J. Mosbacher, R. Schoepfer, H. Monyer, N. Burnashev, P. Seeburg, J. Ruppersberg
- 11 November 1994
These findings suggest that rapid desensitization of AMPA receptors can be regulated by the expression and alternative splicing of GluR-D gene transcripts.
Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS.
These results identify a switch in the molecular and functional properties of glutamate receptors operated by alternative splicing.