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Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study.
TLDR
The selective down-regulation of RELN and GAD(67) in prefrontal cortex of patients with schizophrenia and bipolar disorder who have psychosis is consistent with the hypothesis that these parameters are vulnerability factors in psychosis; this plus the loss of the correlation between these 2 parameters that exists in nonpsychotic subjects support the hypotheses that these changes may be liability factors underlying psychosis.
Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine.
TLDR
The normalization of CSF ALLO content in depressed patients appears to be sufficient to mediate the anxiolytic and antidysphoric actions of fluoxetine or fluvoxamine via its positive allosteric modulation of GABA type A receptors.
A decrease of reelin expression as a putative vulnerability factor in schizophrenia.
TLDR
In all of the brain areas studied, RELN and its mRNA were significantly reduced in patients with schizophrenia; this decrease was similar in patients affected by undifferentiated or paranoid schizophrenia and is interpreted within a neurodevelopmental/vulnerability "two-hit" model for the etiology of schizophrenia.
Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse
TLDR
It is suggested that reelin may be a factor in the dynamic expression of cortical dendritic spines perhaps by promoting integrin receptor clustering.
Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
TLDR
It is demonstrated that 5α-R type I and 3α-HSD colocalize in cortical, hippocampal, and olfactory bulb glutamatergic principal neurons and in some output neurons of the amygdala and thalamus, and data suggest that ALLO and THDOC modulate GABA action at GABAA receptors, either with an autocrine or a paracrine mechanism or by reaching GabAA receptor intracellular sites through lateral membrane diffusion.
Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats.
TLDR
In adult rat cerebellum, Reelin is expressed in glutamatergic neurons (granule cells), and the translated product of this mRNA is readily exported from the granule cell somata to the parallel fibers, where it has been detected by electron microscopy in axon terminals located presynaptically to Purkinje cell dendrites.
Reelin promoter hypermethylation in schizophrenia.
TLDR
The data show that this promoter region has positive and negative properties and that the function of this complex cis element relates to its methylation status.
The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases
TLDR
MS-275 is a potent brain region-selective HDAC inhibitor and, in addition to MS-275, other benzamide derivatives, such as sulpiride, are brain-region selective inhibitors of HDACs.
Influence of recombinant gamma-aminobutyric acid-A receptor subunit composition on the action of allosteric modulators of gamma-aminobutyric acid-gated Cl- currents.
TLDR
Both imidazopyridines (alpidem and zolpidem) were virtually ineffective at modulating the GABA response of alpha 5 beta 1 gamma 2 receptors and in almost all the receptors assembled from alpha 1, alpha 2, alpha 3 or alpha 5 subunits together with beta 1 and gamma 1 subunits.
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