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imazodan

Known as: 4,5-dihydro-6-(4-(1H-imidazol-1-yl)phenyl)-3(2H)-pyridazinone 
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

CI 914imazodan hydrochloride

Broader (3)

Cardiotonic AgentsPhosphodiesterase InhibitorsPyridazines

Papers overview

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1991
1991
Bronchial vs. cardiovascular activities of selective phosphodiesterase inhibitors in the anesthetized beta-blocked dog.
This study was undertaken to determine whether isozyme-specific inhibitors of cAMP-selective phosphodiesterases (PDEs) induce… 
1991
1991
Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue.
1990
1990
Inotropic and chronotropic profile of MCI-154: comparison with isoproterenol and imazodan in guinea pig cardiac preparations.
Although recent studies indicate that MCI-154 exerts novel positive inotropic actions in heart muscle, the chronotropic… 
Review
1989
Review
1989
Biochemical aspects of inhibition of cardiovascular low (Km) cyclic adenosine monophosphate phosphodiesterase.
1989
1989
Subcellular distribution of high-affinity type IV cyclic AMP phosphodiesterase activities in rabbit ventricular myocardium: relations to post-natal maturation.
1989
1989
Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive…
A novel series of analogues of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl) phenyl]ethenyl]-3(2H)-pyridazinone was synthesized as a… 
Highly Cited
1988
Highly Cited
1988
Differential pharmacologic sensitivity of cyclic nucleotide phosphodiesterase isozymes isolated from cardiac muscle, arterial and airway smooth muscle.
Highly Cited
1987
Highly Cited
1987
Subclasses of cyclic AMP phosphodiesterase in cardiac muscle.
1987
1987
Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogues of imazodan (CI-914).
A series of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones was synthesized and evaluated for positive inotropic… 
1986
1986
The Effect of the Cardiotonic Imazodan (CI‐914) on Myocardial and Peripheral Hemodynamics in the Anesthetized Dog
Summary: The purpose of this study was to evaluate the effect of the new cardiotonic, imazodan (CI-914), on myocardial… 
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