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CI 914

Known as: CI-914 
National Institutes of Health

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Broader (1)

imazodan

Papers overview

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1991
1991
Synthesis and Pharmacological Evaluation of 6‐(7‐Theophylline)‐3(2H)‐Pyridazinone: Synthese und Pharmakologische Prüfung von 6‐(7‐Theophyllin) 3(2H)‐pyridazinon
Since the introduction of theophylline (1) as the first PDE-inhibitor used in the treatment of asthma, there has been intense… 
1990
1990
Examination of relative rates of cAMP synthesis and degradation in crude membranes of adipocytes treated with hormones.
The impact of changes in the activation state of the low Km cAMP phosphodiesterase (PDE) on cAMP output in adipocyte membranes… 
1990
1990
[Selective inhibition of CI-914 on the production of TXA2 and HHT].
The effects of CI-914, a novel cardiotonic agent, on AA metabolism in rat neutrophils and platelets in vitro were investigated… 
1990
1990
Inotropic and Chronotropic Profile of MCI-154: Comparison with Isoproterenol and Imazodan in Guinea Pig Cardiac Preparations
Summary: Although recent studies indicate that MCI-154 exerts novel positive inotropic actions in heart muscle, the chronotropic… 
Highly Cited
1987
Highly Cited
1987
Subclasses of cyclic AMP phosphodiesterase in cardiac muscle.
1987
1987
Cardiotonic agents. 6. Synthesis and inotropic activity of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones: ring-contracted analogues of imazodan (CI-914).
A series of 2,4-dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-3H-pyrazol-3-ones was synthesized and evaluated for positive inotropic… 
1986
1986
The Effect of the Cardiotonic Imazodan (CI‐914) on Myocardial and Peripheral Hemodynamics in the Anesthetized Dog
Summary: The purpose of this study was to evaluate the effect of the new cardiotonic, imazodan (CI-914), on myocardial… 
1986
1986
Hemodynamic effects of a new type III phosphodiesterase inhibitor (CI-914) for congestive heart failure.
1986
1986
Effects of CI-914 in congestive heart failure due to coronary artery disease or idiopathic cardiomyopathy.
1985
1985
Relationship between inhibition of cardiac muscle phosphodiesterases, changes in cyclic nucleotide levels, and contractile response for CI-914 and other novel cardiotonics.
In the present study, the inhibitory effects of CI-914, a novel cardiotonic agent, as well as other recently identified positive… 
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