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1-Methyl-8 β-carbobenzyloxy-aminomethyl-10 α-ergoline, a Potent and Long-lasting 5-Hydroxytryptamine Antagonist

A potent and exceptionally long-lasting 5HT antagonist, namely the 1-methyl-8 β-carbobenzyloxy-aminomethyl-10 α-ergoline (MCE), a new compound synthesized in the laboratories1, the structural formula of which is: Its LD50 is 85mg/kg intraperitoneally and 430 mg/kg per os in mice; and about 20 mg/ kg intravenously in rabbits.
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Selective antagonism of dopamine by apomorphine

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Synthesis and Pharmacological Evaluation of 6‐(7‐Theophylline)‐3(2H)‐Pyridazinone: Synthese und Pharmakologische Prüfung von 6‐(7‐Theophyllin) 3(2H)‐pyridazinon

The synthesis and pharmacological profile of 6-(7-theophylline)-3(2H)-pyridazinone is reported, which shows a bronchospasmolytic effect more marked than that of xanthines.
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IN-VITRO DECARBOXYLATION OF NEW PHENYLALANINE DERIVATIVES.

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Antagonism of central effects of tryptamine and 5-hydroxytryptophan by 1,6-dimethyl-8β-carbobenzyloxy-aminomethyl-10α-ergoline

MCE enhanced up to 27 and 30 per cent the motility of rats treated intraperitoneally with 2 and 10 mg/kg of amphetamine, but did not influence the sedation after reserpine, and antagonized tryptamine clonus and 5-HTP head-twitch in a long-lasting way.
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Sim6080, A new calcium antagowist. “In vitro” pharmacological characterization

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Neuro-pharmacological studies on SB 5833, a new psychotherapeutic agent of the benzodiazepine class.

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Effect of camazepam (SB-5833), a new antianxious drug, on cardiac contractility and coronary hemodynamics.

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A NOTE ON THE OXIDATIVE DEAMINATION OF ISOMERS OF 5‐HYDROXYTRYPTAMINE AND OTHER INDOLEALKYLAMINES

5‐Methoxytryptamine and tryptamine are substrates for amine oxidase as good as, or better than, 5‐hydroxytryptamine, whereas iso‐5‐Hydroxytryptionamine and iso‐tryptamines are oxidised less readily than 5‐ hydroxyt Kryptamine andtryptamine.
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Effect of ibopamine on diuresis and arterial blood pressure in anesthetized rats and its interactions with dopaminergic and alpha- and beta-adrenergic antagonists.

It is demonstrated that ibopamine, administered orally at doses of 12.5 to 200 mg/kg, caused a dose-dependent diuresis and the increase in blood pressure in anesthetized rats was antagonized by phenoxybenzamine only.
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