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Sigma1 receptors (σ1Rs) represent a structurally unique class of intracellular proteins that function as chaperones. σ1Rs… Expand The σ receptor was originally proposed to be a subtype of the opioid receptor. However, it is now clear that σ receptors are… Expand The sigma receptor was originally proposed to be a subtype of the opioid receptor. However, it is now clear that sigma receptors… Expand AbstractRationaleCocaine-seeking behavior can be investigated in rodents using the conditioned place preference (CPP) paradigm… Expand In utero cocaine (IUC) exposure results in offspring rats in complex neurochemical and behavioral alterations, particularly… Expand Previous studies have shown that σ receptors are overexpressed in tumor cells. However, the role of σ receptors remains enigmatic… Expand The ς1 receptor is critically involved in the rewarding effect of cocaine, as measured using the conditioned place preference… Expand Igmesine is a selective sigma (sigma(1)) ligand that was reported to exert antidepressant action through an unknown mechanism of… Expand BACKGROUND Cholera toxin, andEscherichia coli heat labile (LT) and heat stable (STa) enterotoxins induce small intestinal… Expand BACKGROUND & AIMS
Igmesine, a final sigma ligand, has been shown to inhibit intestinal secretion and diarrhea in animal models… Expand