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idoxifene

Known as: Pyr-I-Tam, 4-iodopyrrolidinotamoxifen, 1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-butenyl]phenoxy]ethyl]pyrrolidine 
A drug that blocks the effects of estrogen.
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Estrogen AntagonistsTamoxifen
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Histologic changes in ovary, uterus, vagina, and mammary gland of mature beagle dogs treated with the SERM idoxifene.
BACKGROUND Idoxifene is a selective estrogen receptor modulator similar to tamoxifen but is no longer in pharmaceutical… 
2002
2002
Comparison of the effects of EM‐652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW‐5638 and raloxifene on the growth of human ZR‐75‐1 breast tumors in nude mice
EM‐652 exerts pure antiestrogenic activity in the mammary gland and endometrium, while tamoxifen, the antiestrogen most widely… 
Review
2001
Review
2001
Effects of SERMs on important indicators of cardiovascular health: lipoproteins, hemostatic factors, and endothelial function.
Highly Cited
2000
Highly Cited
2000
Antiproliferative effects of idoxifene in a placebo-controlled trial in primary human breast cancer.
Idoxifene is a novel selective estrogen receptor modulator. It has reduced agonist activity on breast and uterine cells compared… 
2000
2000
Selective Estrogen Receptor Modulator Idoxifene Inhibits Smooth Muscle Cell Proliferation, Enhances Reendothelialization, and Inhibits Neointimal Formation In Vivo After Vascular Injury
Background—Idoxifene (ID) is a tissue-selective estrogen receptor modulator (SERM). The pharmacological profile of ID in animal… 
Highly Cited
2000
Highly Cited
2000
Cross-resistance of triphenylethylene-type antiestrogens but not ICI 182,780 in tamoxifen-stimulated breast tumors grown in athymic mice.
The triphenylethylene antiestrogens, idoxifene (Idox) and toremifene (Tor), are structurally related analogues of tamoxifen (Tam… 
1999
1999
Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.
The drug tamoxifen shows evidence of genotoxicity, and induces liver tumours in rats. Covalent DNA adducts have been detected in… 
1998
1998
Structure-activity relationships for triphenylethylene antiestrogens on hepatic phase-I and phase-II enzyme expression.
1998
1998
Length increase of the side chain of idoxifene does not improve its antagonistic potency in breast-cancer cell lines
Abstract Linkage of specific residues onto steroidal estrogens through a long aliphatic side chain leads to “pure antiestrogens… 
Highly Cited
1994
Highly Cited
1994
Inhibition of volume-activated I- and taurine efflux from HeLa cells by P-glycoprotein blockers correlates with calmodulin inhibition.
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