• Publications
  • Influence
Polycyclic aromatic hydrocarbons in the diet.
  • D. Phillips
  • Environmental Science
    Mutation research
  • 15 July 1999
Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.
SNPs in the NER genes ERCC1 (Asn118Asn, 15310G>C, 8902G>T), XPA (-4G>A), ERCC2/XPD (Lys751Gln) and ERCC5/X PD (His46His) and MGMT/AGT(Lys178Arg) were found to modulate NSCLC risk.
Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.
Twenty-three naturally occurring and synthetic alkenylbenzene derivatives structurally related to the hepatocarcinogen safrole were assayed for their hepatocARCinogenicity in mice to identify benign skin tumors that could be promoted with croton oil.
Mutational signatures associated with tobacco smoking in human cancer
The results are consistent with the proposition that smoking increases cancer risk by increasing the somatic mutation load, although direct evidence for this mechanism is lacking in some smoking-related cancer types.
Diversity of TMPRSS2-ERG fusion transcripts in the human prostate
Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.
32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice.
All but one of the alkenylbenzenes studied became bound to newborn mouse-liver DNA, but the levels and the persistence of adducts formed by the carcinogenic compounds were greater.
Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols.
A recommended set of procedures has been developed for the detection and quantitation of DNA adducts formed by PAHs, aromatic amines and methylating agents and there is a set of standard DNA samples for use in quality control and against which biological samples can be normalized.
Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme.
Since the publication of the International Programme on Chemical Safety (IPCS) Harmonized Scheme for Mutagenicity Testing, there have been a number of publications addressing test strategies for
Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.
The results consistently indicated that the GSTM1 null genotype was associated with a slightly increased lung cancer risk and patients with the combination null and AG or GG had significantly higher adduct levels than all other genotype combinations.