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ibudilast

Known as: Pyrazolo(1,5-a)pyridine, 3-isobutyryl-2-isopropyl-, Ibudilastum, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine 
 
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
BACKGROUND There are limited treatments for progressive multiple sclerosis. Ibudilast inhibits several cyclic nucleotide… Expand
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2016
2016
BACKGROUND Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS… Expand
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Highly Cited
2015
Highly Cited
2015
Neuroinflammatory signaling pathways in the central nervous system are of current interest as potential pharmacotherapy targets… Expand
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Highly Cited
2010
Highly Cited
2010
Background: Ibudilast is a phosphodiesterase inhibitor influencing inflammation and neurodegeneration in multiple sclerosis (MS… Expand
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Highly Cited
2010
Highly Cited
2010
AV411 (ibudilast; 3-isobutyryl-2-isopropylpyrazolo-[1,5-a]pyridine) is an antiinflammatory drug that was initially developed for… Expand
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Highly Cited
2009
Highly Cited
2009
Morphine-induced glial proinflammatory responses have been documented to contribute to tolerance to opioid analgesia. Here, we… Expand
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Review
2007
Review
2007
The treatment of neuropathic pain is a major unresolved medical challenge. Present pharmacotherapies only have modest efficacy… Expand
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Highly Cited
2006
Highly Cited
2006
Ibudilast is widely used in Japan to treat ischemic stroke and bronchial asthma. Its mode of action is through the inhibition of… Expand
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Highly Cited
2004
Highly Cited
2004
The phosphodiesterase inhibitor, ibudilast, has many effects on lymphocytes, endothelial cells, and glial cells. We examined the… Expand
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Highly Cited
1999
Highly Cited
1999
Tumor necrosis factor alpha (TNFalpha) is considered to play a critical role in the development of various pathological processes… Expand
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