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SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models.
- T. Matsuda, N. Arakawa, A. Baba
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 July 2001
Results indicate that SEA0400 is the most potent and selective inhibitor of NCX, and suggest that the compound may exert protective effects on postischemic brain damage.
Astrocyte apoptosis: implications for neuroprotection
Altered psychomotor behaviors in mice lacking pituitary adenylate cyclase-activating polypeptide (PACAP)
- H. Hashimoto, N. Shintani, A. Baba
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 30 October 2001
Evidence is provided that PACAP plays a previously uncharacterized role in the regulation of psychomotor behaviors, as well as the generation of mice lacking the PACAP gene (PACAP−/−), which displayed remarkable behavioral changes.
Distribution of the mRNA for a pituitary adenylate cyclase‐activating polypeptide receptor in the rat brain: An in situ hybridization study
Moderate‐to‐weak expression was further observed in many other regions of the brain and in the cerebellar cortex, and presumed Bergmann glia cells showed moderate expression.
Pituitary adenylate cyclase-activating polypeptide (PACAP) decreases ischemic neuronal cell death in association with IL-6.
Pituitary adenylate cyclase-activating polypeptide prevents neuronal cell death after ischemia via a signaling mechanism involving IL-6, and phosphorylated STAT, pSTAT3 and pERK were observed in the PACAP(+/-) mice, whereas a reduction in p STAT3 was recorded in the IL- 6 null mice.
Apelin is a novel angiogenic factor in retinal endothelial cells.
Astrocytes Modulate Neural Network Activity by Ca2+-Dependent Uptake of Extracellular K+
It is shown here that astrocytic Ca2+ signaling ex vivo and in vivo stimulated the Na+,K+-ATPase (Na+- and K+-dependent adenosine triphosphatase) leading to a transient decrease in the extracellular potassium ion (K+) concentration, which led to neuronal hyperpolarization and suppressed baseline excitatory synaptic activity.
Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3.
Molecular Determinants of Na+/Ca2+ Exchange (NCX1) Inhibition by SEA0400*
The results suggest that Phe-213, Gly-833, and residues that eliminate Na+-dependent inactivation are critical determinants for the inhibition by SEA0400, and their mutants are very useful for checking the pharmacological importance of NCX inhibition bySEA0400.
KB-R7943 inhibits store-operated Ca(2+) entry in cultured neurons and astrocytes.
- N. Arakawa, M. Sakaue, T. Matsuda
- Biology, ChemistryBiochemical and biophysical research…
- 20 December 2000
Results indicate that cultured neurons and astrocytes possess SOCE and that KB-R7943 inhibits not only NCX but also SOCE.