Ibudilast (AV-411)

@article{Ledeboer2007Ibudilast,
  title={Ibudilast (AV-411)},
  author={Annemarie Ledeboer and Mark R Hutchinson and Linda R Watkins and Kirk W Johnson},
  journal={Expert Opinion on Investigational Drugs},
  year={2007},
  volume={16},
  pages={935 - 950}
}
The treatment of neuropathic pain is a major unresolved medical challenge. Present pharmacotherapies only have modest efficacy and numerous side effects. The use of opioid analgesics is additionally coupled with dependence and withdrawal syndromes. Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation. It has been used clinically for other indications with a good safety profile. As glial cell activation is considered to crucially… 

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...