Ibudilast (AV-411)

  title={Ibudilast (AV-411)},
  author={A. Ledeboer and M. Hutchinson and L. Watkins and K. Johnson},
  journal={Expert Opinion on Investigational Drugs},
  pages={935 - 950}
  • A. Ledeboer, M. Hutchinson, +1 author K. Johnson
  • Published 2007
  • Medicine
  • Expert Opinion on Investigational Drugs
  • The treatment of neuropathic pain is a major unresolved medical challenge. Present pharmacotherapies only have modest efficacy and numerous side effects. The use of opioid analgesics is additionally coupled with dependence and withdrawal syndromes. Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation. It has been used clinically for other indications with a good safety profile. As glial cell activation is considered to crucially… CONTINUE READING
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    Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
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