Ibudilast (AV-411)

@article{Ledeboer2007Ibudilast,
  title={Ibudilast (AV-411)},
  author={A. Ledeboer and M. Hutchinson and L. Watkins and K. Johnson},
  journal={Expert Opinion on Investigational Drugs},
  year={2007},
  volume={16},
  pages={935 - 950}
}
  • A. Ledeboer, M. Hutchinson, +1 author K. Johnson
  • Published 2007
  • Medicine
  • Expert Opinion on Investigational Drugs
  • The treatment of neuropathic pain is a major unresolved medical challenge. Present pharmacotherapies only have modest efficacy and numerous side effects. The use of opioid analgesics is additionally coupled with dependence and withdrawal syndromes. Ibudilast (AV-411) is a non-selective phosphodiesterase inhibitor that is also known to suppress glial cell activation. It has been used clinically for other indications with a good safety profile. As glial cell activation is considered to crucially… CONTINUE READING
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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 145 REFERENCES
    The glial modulatory drug AV411 attenuates mechanical allodynia in rat models of neuropathic pain.
    • 117
    Gabapentin in the treatment of neuropathic pain
    • 161
    Glia: novel counter-regulators of opioid analgesia
    • 287
    Advances in neuropathic pain: diagnosis, mechanisms, and treatment recommendations.
    • 1,181
    • PDF
    Neuropathic pain and spinal microglia: a big problem from molecules in ‘small’ glia
    • 678