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REVIEW: The alcohol‐preferring P rat and animal models of excessive alcohol drinking
Findings indicate that the P rat can be effectively used in models assessing alcohol‐preference, a genetic predisposition for alcohol abuse and/or alcoholism, and excessive drinking using protocols of binge‐like or relapse‐like drinking.
Phenotypic and Genotypic Characterization of the Indiana University Rat Lines Selectively Bred for High and Low Alcohol Preference
The elucidation of the genotypes and phenotypes that result in excessive alcohol intake may lead to a better understanding of alcohol abuse and alcoholism and could guide strategies for potential treatment and prevention.
Intracranial Self-Administration of Ethanol within the Ventral Tegmental Area of Male Wistar Rats: Evidence for Involvement of Dopamine Neurons
The results of this study indicate that EtOH is reinforcing within the posterior VTA of male Wistar rats and suggest that activation of VTA DA neurons is involved in this process.
The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamine.
Salsolinol produces reinforcing effects in the posterior VTA of Wistar rats, and these effects are mediated by activation of DA neurons and local 5-HT3 receptors.
Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats
Findings indicate that alcohol drinking patterns differ across the age and sex of P rats, which suggests that the effectiveness of treatments for reducing excessive alcohol intake may vary depending upon the Age and/or sex of the subjects being tested.
Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats.
Subregion specific, ethanol-induced increases in mGluR/Homer2/NR2 expression within the NAC and amygdala suggest changes in glutamatergic plasticity had taken place in these brain structures, which may, in part, mediate the chronic relapsing nature of alcohol abuse.
Regional Heterogeneity for the Intracranial Self-Administration of Ethanol and Acetaldehyde within the Ventral Tegmental Area of Alcohol-Preferring (P) Rats: Involvement of Dopamine and Serotonin
The results of this study indicate that EtOH and ACD can independently produce reinforcing effects within the posterior VTA, and that activation of DA neurons mediates these effects.
Effects of Repeated Alcohol Deprivations on Operant Ethanol Self-Administration by Alcohol-Preferring (P) Rats
The results suggest that repeated cycles of alcohol deprivation and alcohol access increased the reinforcing effects of ETOH in the P rats.
Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats.
AIMS Changes in glutamatergic transmission affect many aspects of neuroplasticity associated with ethanol and drug addiction. For instance, ethanol- and drug-seeking behavior is promoted by increased
Recent advances in animal models of alcohol craving and relapse
Overall, the findings indicate substantial progress has been made in developing animal models of alcohol abuse, relapse and craving using these selectively bred rat lines, as well as outbred rats.