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Cyclic GMP pathway is critical for inducing long–term sensitization of nociceptive sensory neurons
Noxious stimulation can trigger persistent sensitization of somatosensory systems that involves memory–like mechanisms. Here we report that noxious stimulation of the mollusc Aplysia producesExpand
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Mechanoafferent neurons innervating tail of Aplysia. I. Response properties and synaptic connections.
Mechanical, chemical, or electrical stimulation of the tail elicits a short-latency (less than 1 s) tail-withdrawal reflex that is graded with the intensity of the stimulus. The tail-withdrawalExpand
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Induction of monocyte chemoattractant protein-1 (MCP-1) and its receptor CCR2 in primary sensory neurons contributes to paclitaxel-induced peripheral neuropathy.
UNLABELLED The use of paclitaxel (Taxol), a microtubule stabilizer, for cancer treatment is often limited by its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]),Expand
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Persistent Pain after Spinal Cord Injury Is Maintained by Primary Afferent Activity
Chronic pain caused by insults to the CNS (central neuropathic pain) is widely assumed to be maintained exclusively by central mechanisms. However, chronic hyperexcitablility occurs in primaryExpand
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Defensive responses of larval Manduca sexta and their sensitization by noxious stimuli in the laboratory and field.
Sensitization of defensive responses following noxious stimulation occurs in diverse species, but no demonstration of nociceptive sensitization in insects has been reported. A set of defensiveExpand
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Classical conditioning in a simple withdrawal reflex in Aplysia californica
The ability of Aplysia and other gastropod molluscs to exhibit complex behaviors that can be modified by associative learning has encouraged us to search for an elementary behavior controlled by aExpand
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Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain
Loose ligation of a rat's sciatic nerve produces hyperalgesia to thermal stimuli and elicits guarding behavior directed at the afflicted paw. The present experiments test whether localizedExpand
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Priming events and retrograde injury signals. A new perspective on the cellular and molecular biology of nerve regeneration.
Successful axon regeneration requires that signals from the site of injury reach the nucleus to elicit changes in transcription. In spite of their obvious importance, relatively few of these signalsExpand
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Somatotopic organization and functional properties of mechanosensory neurons expressing sensorin‐A mRNA in Aplysia californica
A previous study reported that a peptide, sensorin‐A, is expressed exclusively in mechanosensory neurons having somata in central ganglia of Aplysia. The present study utilized in situ hybridization,Expand
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Mechanoafferent neurons innervating tail of Aplysia. II. Modulation by sensitizing stimulation.
The tail-withdrawal reflex of Aplysia can be sensitized by weak stimulation of a site outside the site used to test the reflex or by repeatedly stimulating the test site itself. The sensitization ofExpand
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