herbimycin

Known as: 17-Demethoxy-15-methoxy-11-O-methylgeldanamycin, (15R)-, geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-, Herbimycin A 
A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Herbimycin binds to and inhibits the cytosolic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2016
05010015019792016

Papers overview

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Highly Cited
1998
Highly Cited
1998
Cyclin D expression is regulated by growth factors and is necessary for the induction of mitogenesis. Herbimycin A, a drug that… (More)
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Highly Cited
1998
Highly Cited
1998
Purpose: Benzoquinone ansamycins are antibiotics with anticancer potential. First described as tyrosine kinase inhibitors, they… (More)
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Highly Cited
1996
Highly Cited
1996
Human neutrophils, monocytes, and eosinophils are known to undergo apoptotic cell death. The Fas/Fas ligand pathway has been… (More)
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Highly Cited
1995
Highly Cited
1995
Integrin receptors play important roles in organizing the actin-containing cytoskeleton and in signal transduction from the… (More)
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Highly Cited
1995
Highly Cited
1995
Herbimycin A is an ansamycin antibiotic isolated as an agent that reverses morphological transformation induced by v-src… (More)
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Highly Cited
1994
Highly Cited
1994
The molecular mechanisms by which oncogenic tyrosine kinases induce cellular transformation are unclear. Herbimycin A… (More)
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Highly Cited
1992
Highly Cited
1992
Cells in culture reveal high levels of protein tyrosine phosphorylation in their focal adhesions, the regions where cells adhere… (More)
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Highly Cited
1992
Highly Cited
1992
Rat 3Y1 cells acquire metastatic potential when transformed with v-src, and this potential is enhanced by double transformation… (More)
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1988
1988
We studied the effectiveness of herbimycin A, an inhibitor of the function of the temperature-sensitive src oncogene, to reverse… (More)
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1979
1979
Herbimycin, a new antibiotic, was isolated from the fermentation broth of Streptomyces hygroscopicus strain No. AM-3672, a soil… (More)
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