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herbimycin

Known as: 17-Demethoxy-15-methoxy-11-O-methylgeldanamycin, (15R)-, geldanamycin, 17-demethoxy-15-methoxy-11-O-methyl-, (15R)-, Herbimycin A 
A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus. Herbimycin binds to and inhibits the cytosolic… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (4)

Anti-Bacterial AgentsAntibiotics, AntineoplasticEnzyme InhibitorsRifabutin
HSP90 Heat-Shock ProteinsNCIt Antineoplastic Agent TerminologySignal Transduction Inhibitionanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2000
Highly Cited
2000
The role of protein-tyrosine phosphorylation and gelatinase production in the migration and proliferation of smooth muscle cells.
1997
1997
Phosphatidic acid elicits calcium mobilization and actin polymerization through a tyrosine kinase-dependent process in human neutrophils: a mechanism for induction of chemotaxis.
Highly Cited
1996
Highly Cited
1996
Induction of c-jun protooncogene expression by hydrogen peroxide through hydroxyl radical generation and p60SRC tyrosine kinase activation.
1995
1995
APO‐1(CD95)‐mediated apoptosis in Jurkat cells does not involve src kinases or CD45
Highly Cited
1994
Highly Cited
1994
Evidence for involvement of tyrosine phosphorylation in taxol-induced apoptosis in a human ovarian tumor cell line.
Highly Cited
1994
Highly Cited
1994
Characterization of basic fibroblast growth factor-mediated acceleration of axonal branching in cultured rat hippocampal neurons
Highly Cited
1993
Highly Cited
1993
p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals.
Highly Cited
1993
Highly Cited
1993
Activation of protein-tyrosine kinase p72syk with concanavalin A in polymorphonuclear neutrophils.
1992
1992
MARCKS protein is transcriptionally down-regulated in v-Src-transformed BALB/c 3T3 cells.
Highly Cited
1989
Highly Cited
1989
Mechanism of reversion of Rous sarcoma virus transformation by herbimycin A: reduction of total phosphotyrosine levels due to reduced kinase activity and increased turnover of p60v-src1.
We studied the mechanism of reversion of Rous sarcoma virus (RSV)-transformation by herbimycin A in a temperature-sensitive RSV… 
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