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Rapid Ca2+‐mediated activation of Rap1 in human platelets
TLDR
It is concluded that Rap1 activation in platelets is an important common event in early agonist‐induced signalling, and that this activation is mediated by an increased intracellular Ca2+ concentration. Expand
New gene functions in megakaryopoiesis and platelet formation
TLDR
A high-powered meta-analysis of genome-wide association studies (GWAS) in up to 66,867 individuals of European ancestry is carried out, identifying 68 genomic loci reliably associated with platelet count and volume mapping to established and putative novel regulators of megakaryopoiesis and platelet formation. Expand
Sequential Regulation of the Small GTPase Rap1 in Human Platelets
TLDR
It is shown that in platelets, α-thrombin induces Rap1 activation first by a calcium-mediated pathway independently of PKC and then by a second activation phase mediated byPKC and, in part, integrin αIIbβ3. Expand
Reactome – a curated knowledgebase of biological pathways: megakaryocytes and platelets
TLDR
Reactome is introduced, a curated knowledgebase of biological pathways with extensive coverage of pathways relevant to megakaryocytes, platelets and haemostasis that is compared with other data resources for platelets, e.g. the Platelet Web. Expand
A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.
TLDR
Novel insights are provided into key hubs within platelet signaling networks within collagen and adenosine-diphosphate signaling networks. Expand
The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage.
TLDR
A function of MRP4 in platelet mediator storage and inhibition of MRp4 may represent a novel mechanism for inhibition of platelet function by some anti-inflammatory drugs. Expand
Platelet Inhibition by Insulin Is Absent in Type 2 Diabetes Mellitus
TLDR
It is shown in patients with type 2 diabetes mellitus (DM2) that platelets have lost responsiveness to insulin leading to increased adhesion, aggregation, and procoagulant activity on contact with collagen. Expand
Activation of the Small GTPase Ral in Platelets
TLDR
A novel method to measure Ral activation utilizing the Ral binding domain of the putative Ral effector RLIP76 as an activation-specific probe is described and it is shown that Ral can be activated by extracellular stimuli. Expand
Platelet Activation by Oxidized Low Density Lipoprotein Is Mediated by Cd36 and Scavenger Receptor-A
TLDR
A novel platelet-activating pathway stimulated by oxLDL that is initiated by the combined action of CD36 and SR-A is revealed. Expand
Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia
TLDR
A defect of the platelet plasma membrane glycoprotein composition is reported in a patient whose platelets are totally unresponsive to collagen, contributing significantly to present concepts of platelet function. Expand
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