heparanase

Known as: EC 3.2.1.166, Heparanase-1, Endo-Glucoronidase 
Heparanase (543 aa, ~61 kDa) is encoded by the human HPSE gene. This protein plays a role in proteoglycan catabolism.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Adoptive transfer of chimeric antigen receptor (CAR)-redirected T lymphocytes (CAR-T cells) has had less striking therapeutic… (More)
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Highly Cited
2011
Highly Cited
2011
Heparanase (HPSE) is a potent protumorigenic, proangiogenic, and prometastatic enzyme that is overexpressed in brain metastatic… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Heparanase, a mammalian endo-beta-D-glucuronidase, specifically degrades heparan sulfate proteoglycans ubiquitously… (More)
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Highly Cited
2007
Highly Cited
2007
The heparan sulfate (HS) proteoglycan, syndecan-1, plays a major role in multiple myeloma (MM) by concentrating heparin-binding… (More)
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Highly Cited
2005
Highly Cited
2005
Although widespread skeletal dissemination is a critical step in the progression of myeloma, little is known regarding mechanisms… (More)
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Highly Cited
2005
Highly Cited
2005
The molecular mechanisms of heparan sulfate proteoglycan downregulation in the glomerular basement membrane (GBM) of the kidneys… (More)
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2004
2004
In previous studies, we have demonstrated that human heparanase (endo-β-D-glucuronidase) is localized primarily in a perinuclear… (More)
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Review
2001
Review
2001
Studies of the involvement of ECM molecules in cell attachment, growth, and differentiation have revealed a central role of… (More)
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Highly Cited
2000
Highly Cited
2000
The human heparanase gene, an endo-beta-glucuronidase that cleaves heparan sulfate at specific intrachain sites, has recently… (More)
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Highly Cited
2000
Highly Cited
2000
We have cloned a hrp gene cluster from Xanthomonas oryzae pv. oryzae. Bacteria with mutations in the hrp region have reduced… (More)
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