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heparanase

Known as: EC 3.2.1.166, Heparanase-1, Endo-Glucoronidase 
Heparanase (543 aa, ~61 kDa) is encoded by the human HPSE gene. This protein plays a role in proteoglycan catabolism.
National Institutes of Health

Related topics

Related topics

12 relations
Angiogenic ProcessBlood coagulationCell-Matrix JunctionEnzyme Gene

Broader (1)

Beta-glucuronidase

Narrower (2)

HPSE2 protein, humanHpse protein, rat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Heparanase: Historical Aspects and Future Perspectives.
Heparanase is an endo-β-glucuronidase that cleaves at a limited number of internal sites the glycosaminoglycan heparan sulfate… 
2013
2013
Identifying the metastatic seeds of breast cancer
Two studies show that circulating tumor cells from breast cancer patients give rise to metastases in mice. 
Highly Cited
2010
Highly Cited
2010
Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors.
Graft-versus-host disease (GVHD) is the most common cause of nonrelapse mortality and morbidity after hematopoietic stem cell… 
2008
2008
High Expression of Heparanase is Significantly Associated with Dedifferentiation and Lymph Node Metastasis in Patients with Pancreatic Ductal Adenocarcinomas and Correlated to PDGFA and Via HIF1a to…
BackgroundPancreatic cancer still has one of the worst prognoses of all cancers with a 5-year survival rate of 5%, making it… 
2007
2007
Heparanase Expression and Function During Early Pregnancy in Mice1
Abstract Embryo implantation is a complex process that involves interactions between cell-surface and extracellular components of… 
Highly Cited
2002
Highly Cited
2002
Cloning and Characterization of the Human Heparanase-1 (HPR1) Gene Promoter
Heparanase-1 (HPR1) is an endoglycosidase that specifically degrades the heparan sulfate chains of proteoglycan, a component of… 
1998
1998
The frequency of human platelet antigen (HPA) genotypes in the Polish population
The human platelet antigens (HPA1–5) in the Polish population were investigated using the PCR with sequence specific primers (SSP… 
1996
1996
Comparison of extraction techniques, including supercritical fluid, high-pressure solvent, and soxhlet, for organophosphorus hydraulic fluids from soil.
The efficiencies of three extraction techniques for removal of nonpesticidal organophosphates from soil were determined… 
1995
1995
Relationship between chemical and physical indexes and column and HPSE chromatography methods for evaluating frying oil
SummaryStandard chemical and physical indexes, such as color index, acid value, and K270 were compared with the polar content and… 
1975
1975
Adenovirus transcription. II. RNA sequences complementary to simian virus 40 and adenovirus 2DNA in AD2+ND1- and AD2+ND3-infected cells
The genomes of the two nondefective adenovirus 2/simian virus 40 (Ad2/SV 40) hybrid viruses, nondefective Ad2/SV 40 hybrid virus… 
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