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MethyLight: a high-throughput assay to measure DNA methylation.
TLDR
A high-throughput quantitative methylation assay that utilizes fluorescence-based real-time PCR (TaqMan) technology that requires no further manipulations after the PCR step is described, and MethyLight is a highly sensitive assay, capable of detecting methylated alleles in the presence of a 10,000-fold excess of unmethylated allele. Expand
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.
TLDR
The results of this study show that intratumoral gene expression level of DPD is associated with tumor response to 5-FU and that the use of more than one independent determinant of response permits the identification of a high percentage of responding patients. Expand
ERCC1 and thymidylate synthase mRNA levels predict survival for colorectal cancer patients receiving combination oxaliplatin and fluorouracil chemotherapy.
TLDR
It is suggested that intratumoral ERCC1 mRNA and TS mRNA expression levels are independent predictive markers of survival for 5-FU and oxaliplatin combination chemotherapy in 5-fu-resistant metastatic colorectal cancer. Expand
Low ERCC1 expression correlates with prolonged survival after cisplatin plus gemcitabine chemotherapy in non-small cell lung cancer.
TLDR
Everexpression of the excision repair cross-complementing 1 (ERCC1) gene is a predictive factor for survival after CDDP/Gem therapy in advanced NSCLC and the presence of weight loss were significant prognostic factors for survival in a Cox proportional hazards multivariable analysis. Expand
Fluorinated pyrimidines and their nucleosides.
TLDR
This chapter will deal primarily with a review of the major pharmacological and biochemical effects of these compounds and will focus only on key references that are germane to the topics being described. Expand
ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine.
TLDR
This retrospective study further validates ER CC1 and RRM1 genes as reliable candidates for customized chemotherapy and shows a higher impact on the survival of NSCLC patients treated with cisplatin/gemcitabine for ERCC1. Expand
Standing the test of time: targeting thymidylate biosynthesis in cancer therapy
TLDR
The pivotal discoveries that led to the rational development of thymidylate biosynthesis as a chemotherapeutic target are overviewed, and the crucial contribution of these advances to driving and accelerating drug development in the earliest era of cancer chemotherapy is highlighted. Expand
Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer Is correlated with survival.
TLDR
Findings indicate that HER2-neu and EGFR play a crucial role in the biological behavior of NSCLCs and appears to define low- and high-risk groups for treatment failure in curatively resected NSCLC. Expand
Rapid activation of MDR1 gene expression in human metastatic sarcoma after in vivo exposure to doxorubicin.
TLDR
It is demonstrated, for the first time, that MDR1 gene expression can be rapidly activated in human tumors after transient in vivo exposure to cytotoxic chemotherapy. Expand
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
TLDR
The ideas that reductive activation of MMC by DTD may be important in the cytotoxicity of M MC and that polymerase chain reaction may be a useful technique for quantitating the relative expression of genes in human tumors are supported. Expand
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