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HPSE2 protein, human

Known as: heparanase 2 protein, human, Hpa2, heparanase 3 protein, human 
Heparanase-2 (592 aa, ~67 kDa) is encoded by the human HPSE2 gene. This protein is involved in the proteolysis of heparan sulfate proteoglycans.
National Institutes of Health

Related topics

Related topics

9 relations
Enzyme GeneExtracellular Matrix DegradationHPSE2 wt AlleleHomo sapiens

Broader (2)

HPSE2 geneheparanase

Papers overview

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Review
2019
Review
2019
Heparanase: A Challenging Cancer Drug Target
Heparanase has been viewed as a promising anti-cancer drug target for almost two decades, but no anti-heparanase therapy has yet… 
Review
2018
Review
2018
Opposing Functions of Heparanase-1 and Heparanase-2 in Cancer Progression.
2016
2016
The prognostic significance of heparanase expression in metastatic melanoma
Background Heparanase expression is induced in many types of cancers, including melanoma, and promotes tumor growth, angiogenesis… 
2016
2016
Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth.
The endoglycosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an activity that has… 
Highly Cited
2013
Highly Cited
2013
LRIG2 mutations cause urofacial syndrome.
2011
2011
Transcriptional Regulation of Proteoglycans and Glycosaminoglycan Chain-synthesizing Glycosyltransferases by UV Irradiation in Cultured Human Dermal Fibroblasts
Various kinds of glycosaminoglycans (GAGs) and proteoglycans (PGs) have been known to be involved in structural and space-filling… 
2008
2008
Heparanase-2, syndecan-1, and extracellular matrix remodeling in colorectal carcinoma
Aim To propose a quantitative method to detect heparanase-2 (HPA2) and syndecan-1 (Syn-1) using immunohistochemistry in… 
Review
2007
Review
2007
Mammalian heparanase: what is the message?
•  Heparan sulphate proteoglycans ‐  Heparan sulphate ‐  Heparan sulphate interactions ‐  Core proteins •  Heparanase… 
Highly Cited
1999
Highly Cited
1999
Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily.
We report the crystal structure of the yeast protein Hpa2 in complex with acetyl coenzyme A (AcCoA) at 2.4 A resolution and… 
1991
1991
Stepwise cloning and molecular characterization of the HgiDI restriction-modification system from Herpetosiphon giganteus Hpa2.
The restriction-modification system HgiDI from Herpetosiphon giganteus strain Hpa2 has been cloned in E. coli in a two-step… 
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