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HPSE2 protein, human

Known as: heparanase 2 protein, human, Hpa2, heparanase 3 protein, human 
Heparanase-2 (592 aa, ~67 kDa) is encoded by the human HPSE2 gene. This protein is involved in the proteolysis of heparan sulfate proteoglycans.
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Heparanase, the sole heparan sulfate (HS)-degrading endoglycosidase, regulates multiple biological activities that enhance tumor… Expand
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2016
2016
Background Heparanase expression is induced in many types of cancers, including melanoma, and promotes tumor growth, angiogenesis… Expand
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2016
2016
The endoglycosidase heparanase specifically cleaves the heparan sulfate (HS) side chains on proteoglycans, an activity that has… Expand
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2013
2013
Urofacial syndrome (UFS) (or Ochoa syndrome) is an autosomal-recessive disease characterized by congenital urinary bladder… Expand
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2013
2013
Background: Based on their sequences, the closely related yeast Hpa2 and Hpa3 proteins appear to be acetyltransferases. Results… Expand
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2011
2011
Various kinds of glycosaminoglycans (GAGs) and proteoglycans (PGs) have been known to be involved in structural and space-filling… Expand
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2011
2011
OBJECTIVE: To determine the molecules involved in extracellular matrix remodeling and to identify and quantify heparanase… Expand
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2008
2008
Aim To propose a quantitative method to detect heparanase-2 (HPA2) and syndecan-1 (Syn-1) using immunohistochemistry in… Expand
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Highly Cited
1999
Highly Cited
1999
We report the crystal structure of the yeast protein Hpa2 in complex with acetyl coenzyme A (AcCoA) at 2.4 A resolution and… Expand
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1999
1999
Background and Objectives: Chronic refractory autoimmune thrombocytopenic purpura (AITP) is an autoimmune disorder due to… Expand
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