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Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis
Heparan sulfate proteoglycans interact with many extracellular matrix constituents, growth factors and enzymes. Degradation of heparan sulfate by endoglycosidic heparanase cleavage affects a varietyExpand
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Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis.
Studies of the involvement of ECM molecules in cell attachment, growth, and differentiation have revealed a central role of heparan sulfate (HS) proteoglycans (HSPGs) in early embryogenesis,Expand
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The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.
Vascular endothelial growth factor (VEGF) induces the proliferation of endothelial cells and is a potent angiogenic factor that binds to heparin. We have therefore studied the effect of heparin uponExpand
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Thrombin receptor overexpression in malignant and physiological invasion processes
Although the involvement of soluble and matrix-immobilized proteases in tumor cell invasion and metastasis is well recognized, the role of proteolytically activated cell surface receptors has notExpand
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Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.
Heparanase is an endoglycosidase which cleaves heparan sulfate (HS) and hence participates in degradation and remodeling of the extracellular matrix (ECM). Heparanase is preferentially expressed inExpand
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Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.
Bovine aortic and corneal endothelial cells synthesize a growth factor that remains mostly cell-associated but can also be extracted from the subendothelial extracellular matrix (ECM) deposited byExpand
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A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.
The basement membranes of bovine cornea are found to contain an angiogenic endothelial cell mitogen, basic fibroblast growth factor (FGF), as determined by heparin-affinity chromatography,Expand
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VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix*
A vascular endothelial growth factor (VEGF) mRNA species containing exons 1-6 and 8 of the VEGF gene was found to be expressed as a major VEGF mRNA form in several cell lines derived from carcinomasExpand
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Substrate Specificity of Heparanases from Human Hepatoma and Platelets*
Heparan sulfate proteoglycans, attached to cell surfaces or in the extracellular matrix, interact with a multitude of proteins via their heparan sulfate side chains. Degradation of these chains byExpand
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Heparanase Regulates Secretion, Composition, and Function of Tumor Cell-derived Exosomes*♦
Background: Heparanase drives the progression of many tumor types. Results: Heparanase enhances exosome secretion and alters exosome composition and function. Conclusion: Heparanase promotes tumorExpand
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