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Extracellular Matrix Degradation

Extracellular Matrix Degradation consists of conjugation, transport, oxidation, and/or proteolysis of the supporting meshwork-like network of fibers… 
National Institutes of Health

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ADAM15 protein, humanBMS-275291C-Type Mannose Receptor 2CAPN1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR‐26a
Osteoarthritis (OA) is a chronic disease pathologically characterized by articular cartilage degeneration and damage. Currently… 
Highly Cited
2016
Highly Cited
2016
E2 regulates MMP-13 via targeting miR-140 in IL-1β-induced extracellular matrix degradation in human chondrocytes
BackgroundEstrogen deficiency is closely related to the development of menopausal arthritis. Estrogen replacement therapy (ERT… 
Highly Cited
2012
Highly Cited
2012
Silencing of microRNA-101 prevents IL-1β-induced extracellular matrix degradation in chondrocytes
IntroductionExtracellular matrix (ECM) degradation leads to malfunction of the cartilage in osteoarthritis (OA). Inflammatory… 
Highly Cited
2010
Highly Cited
2010
CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation.
CUB domain-containing protein 1 (CDCP1) is a membrane protein that is highly expressed in several solid cancers. We reported… 
Highly Cited
2009
Highly Cited
2009
Lipid rafts and caveolin-1 are required for invadopodia formation and extracellular matrix degradation by human breast cancer cells.
Invadopodia are ventral membrane protrusions through which invasive cancer cells degrade the extracellular matrix. They are… 
Highly Cited
1999
Highly Cited
1999
Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1.
To clarify the mechanism of cartilage degradation induced by mechanical stress, we investigated the influence of cyclic tension… 
Highly Cited
1995
Highly Cited
1995
Transplantation of transduced chondrocytes protects articular cartilage from interleukin 1-induced extracellular matrix degradation.
Gene therapy used in the context of delivering a therapeutic gene(s) to chondrocytes offers a new approach for treating… 
Highly Cited
1992
Highly Cited
1992
Metalloproteinases mediate extracellular matrix degradation by cells from mouse blastocyst outgrowths.
The maintenance and developmental remodeling of extracellular matrix is crucial to such processes as uterine implantation and the… 
Highly Cited
1990
Highly Cited
1990
Inhibition of cancer cell urokinase plasminogen activator by its specific inhibitor PAI-2 and subsequent effects on extracellular matrix degradation.
Isotopically labeled [( 3H]serine, [3H]proline, and [35S]sulfate) subendothelial cell basement membranes were used to determine… 
Highly Cited
1990
Highly Cited
1990
Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.
We have analyzed the role of plasminogen-activator inhibitor type 1 (PAI-1) in the regulation of tumor cell-mediated… 
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