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Differential Regulation of Th1 and Th2 Functions of NKT Cells by CD28 and CD40 Costimulatory Pathways1
- Y. Hayakawa, K. Takeda, H. Yagita, L. Van Kaer, I. Saiki, K. Okumura
- Biology, MedicineThe Journal of Immunology
- 15 May 2001
It is shown that CD28-CD80/CD86 and CD40-CD154 costimulatory pathways differentially contribute to the regulation of Th1 and Th2 functions of Vα14 NKT cells in vivo.
Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2
Results indicate that the phosphorylation of EphA2 at Ser-897 is controlled by RSK and the RSK–EphA 2 axis might contribute to cell motility and promote tumour malignant progression.
Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng.
- M. Mochizuki, Y. Yoo, I. Azuma
- Medicine, BiologyBiological & pharmaceutical bulletin
- 15 September 1995
It is suggested that both ginseng saponins, 20(R)- and 20(S)-ginsenoside-Rg3, possess an ability to inhibit the lung metastasis of tumor cells, and the mechanism of their antimetastatic effect is related to inhibition of the adhesion and invasion of tumor Cells, and also to anti-angiogenesis activity.
Role of CX3CL1/Fractalkine in Osteoclast Differentiation and Bone Resorption1
A novel role of CX3CL1 is demonstrated in osteoblast-induced osteoclast differentiation and the CX 3CL1-CX3CR1 axis may be a novel target for the therapeutic intervention of bone resorbing diseases such as rheumatoid arthritis, osteoporosis, and cancer bone metastasis.
Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer.
The results strongly suggest that the CXCR4/CXC12 axis plays an important role in the development of peritoneal carcinomatosis from gastric carcinoma.
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway.
Results indicate that similar signaling pathways were utilized for the phosphorylations of IkappaBalpha and p65, which further support the idea that both IkappaB and NF-kappaB are substrates for the IKK complex in the activation of NF- kappaB.
Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway*
- H. Sakurai, Shunsuke Suzuki, I. Saiki
- Biology, ChemistryJournal of Biological Chemistry
- 19 September 2003
Results indicate that similar signaling pathways were utilized for the phosphorylations of IκBα and p65, which further support the idea that both IκBs and NF-κB are substrates for the IKK complex in the activation of NF-kkB.
CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and…
The expression of osteopontin (OPN), CD44 variants, and integrins has been correlated with tumorigenesis and metastasis. Here we show that these proteins cooperate to enhance cell motility. First, we…
Role of aminopeptidase N (CD13) in tumor‐cell invasion and extracellular matrix degradation
The invasion of human metastatic tumor cells into Matrigel‐coated filters was inhibited by an anti‐CD 13 MAb, WM15, in a concentration‐dependent manner, but this MAb did not have any effect on tumor‐cell adhesion and migration to the extracellular matrices, which may be involved in tumor‐ cell invasion.
Chemokine receptors in cancer metastasis and cancer cell‐derived chemokines in host immune response
The present review highlights current knowledge about the role of CXCR4 in cancer metastases and discusses the conflicting biological effects of cancer cell‐derived chemokines on cancer progression, using CCL9 and CXCL16 as examples.