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BMS-275291
Known as:
D2163
, N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide
, REBIMASTAT
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A sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits…
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National Institutes of Health
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Related topics
Related topics
9 relations
Angiogenesis Inhibition
Extracellular Matrix Degradation
MMP1 protein, human
MMP14 protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Molecular Interaction Performance of Tumor Angiogenesis Inhibitors
Aravind Setti
,
Smita C. Pawar
2017
Corpus ID: 51964185
When a tumor progresses it requires the nutrition and oxygen to foster uninterrupted cell division, a characteristic feature of…
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2008
2008
Gateways to clinical trials. July-August 2008.
A. Tomillero
,
M. A. Moral
Methods and Findings in Experimental and Clinical…
2008
Corpus ID: 23111308
(-)-Epigallocatechin gallate, 501516, 89-12; Abatacept, Adalimumab, Adefovir dipivoxil, AG-701, Agatolimod sodium, Alefacept…
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2008
2008
The influence of sex on efficacy, toxicity and delivery of treatment in National Cancer Institute of Canada Clinical Trials Group (NCIC CTG) non-small cell lung cancer (NSCLC) chemotherapy trials
P. Wheatley-Price
,
A. L. Maître
,
+4 authors
F. Shepherd
2008
Corpus ID: 74704741
8054 Background: Outcomes in lung cancer may differ by sex, with some studies reporting longer survival in women. Increased…
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2004
2004
Identification and Characterization of 4-[ [ 4-( 2-Butynyloxy ) phenyl ] sulfonyl ]-N-hydroxy-2 , 2-dimethyl-( 3 S )-thiomorpholinecarboxamide ( TMI-1 ) , a Novel Dual Tumor Necrosis Factor…
Yuhua Zhang
,
Jun Xu
,
+16 authors
Glenn Larsen
2004
Corpus ID: 5348390
Tumor necrosis factor (TNF)is a well validated therapeutic target for the treatment of rheumatoid arthritis. TNFis initially…
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2003
2003
The Biology Behind Matrix Metalloproteinases, Angiogenesis, and Cancer Commentary A. C. Lockhart et al ., Reduction of Wound Angiogenesis in Patients Treated with BMS-275291, a Broad Spectrum Matrix…
J. Rundhaug
2003
Corpus ID: 10742849
as well as TGF (cid:1) , and hidden integrin-binding sites on the ECM fragments are exposed, triggering integrin signaling, which…
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Review
2001
Review
2001
D1927 and D2163
A. Baxter
,
J. Bird
,
+7 authors
R. Jackson
2001
Corpus ID: 85679747
This chapter aims to provide a historical perspective of the Chiroscience matrix metalloproteinase inhibitor (MMPI) program…
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