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MMP14 protein, human
Known as:
MMP-14
, Membrane-Type-1 Matrix Metalloproteinase
, membrane-type 1 matrix metalloproteinase, human
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Matrix metalloproteinase-14 (582 aa, ~66 kDa) is encoded by the human MMP14 gene. This protein is involved in both extracellular matrix proteolysis…
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National Institutes of Health
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Related topics
Related topics
13 relations
BMS-275291
Enzyme Gene
Hydrolysis
Inhibition of Matrix Metalloproteinases Pathway
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Broader (1)
membrane-type 1 matrix metalloproteinase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Phenotype Identifies Poor Prognosis Colorectal Cancers
S. Curran
,
S. R. Dundas
,
J. Buxton
,
M. F. Leeman
,
Robin Ramsay
,
G. Murray
Clinical Cancer Research
2004
Corpus ID: 25581801
Purpose: The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes involved in tumor invasion; several individual…
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Review
2003
Review
2003
MT1-MMP and MMP-7 in invasion and metastasis of human cancers
T. Shiomi
,
Y. Okada
Cancer Metastasis Review
2003
Corpus ID: 2738063
Previous experimental and biochemical studies on matrix metalloproteinases (MMPs) have indicated that MMPs are implicated in…
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Highly Cited
2001
Highly Cited
2001
Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin‐3‐gallate
S. Garbisa
,
L. Sartor
,
S. Biggin
,
B. Salvato
,
R. Benelli
,
A. Albini
Cancer
2001
Corpus ID: 25184947
Given the association of consumption of green tea with prevention of cancer development, metastasis, and angiogenesis, the effect…
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Highly Cited
2001
Highly Cited
2001
Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis
Aixiang Jiang
,
K. Lehti
,
Xing Wang
,
S. Weiss
,
J. Keski‐oja
,
D. Pei
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 24792032
Membrane-type matrix metalloproteinase 1 (MT1-MMP) plays a critical role in extracellular matrix remodeling under both…
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Highly Cited
2001
Highly Cited
2001
Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas
N. Théret
,
O. Musso
,
+5 authors
B. Clement
Hepatology
2001
Corpus ID: 31665794
Matrix metalloproteinase‐2 (MMP2) is a key enzyme in the process of extracellular matrix remodeling involved in tumor invasion…
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Highly Cited
2001
Highly Cited
2001
Rac1 Mediates Type I Collagen-dependent MMP-2 Activation
Y. Zhuge
,
Jiahua Xu
Journal of Biological Chemistry
2001
Corpus ID: 42434306
Cell migration and proteolysis are two essential processes during tumor invasion and metastasis. Matrix metalloproteinase (MMP)-2…
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Highly Cited
2000
Highly Cited
2000
Regulation of Membrane-type-1 Matrix Metalloproteinase Activity by Its Cytoplasmic Domain*
K. Lehti
,
Heli Valtanen
,
S. Wickström
,
J. Lohi
,
J. Keski‐oja
Journal of Biological Chemistry
2000
Corpus ID: 26273885
Membrane-type-1 matrix metalloproteinase (MT1-MMP) has transmembrane and cytoplasmic domains, which target it to invasive fronts…
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Highly Cited
1999
Highly Cited
1999
Expression of MMP‐2 and MMP‐9, their inhibitors, and the activator MT1‐MMP in primary breast carcinomas
J. L. Jones
,
P. Glynn
,
R. Walker
Journal of Pathology
1999
Corpus ID: 30885285
Enhanced expression of the type IV collagenases MMP‐2 and MMP‐9, or lack of their inhibitors TIMP‐1 and TIMP‐2, has been…
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Highly Cited
1999
Highly Cited
1999
Fibronectin upregulates gelatinase B (MMP-9) and induces coordinated expression of gelatinase A (MMP-2) and its activator MT1-MMP (MMP-14) by human T lymphocyte cell lines. A process repressed…
J. Esparza
,
C. Vilardell
,
+5 authors
M. Cid
Blood
1999
Corpus ID: 6274110
T-lymphocyte migration into tissues requires focal degradation of the basement membrane. In this study, we show that transient…
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Highly Cited
1998
Highly Cited
1998
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surface.
K. Lehti
,
J. Lohi
,
Heli Valtanen
,
J. Keski‐oja
Biochemical Journal
1998
Corpus ID: 36429567
Human fibroblasts and HT-1080 fibrosarcoma cells express membrane-type-1 matrix metalloproteinase (MT1-MMP), the cell surface…
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