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membrane-type 1 matrix metalloproteinase

Known as: Membrane Type 1 Matrix Metalloproteinase, Metalloproteinase, MMP14, Membrane Type Matrix Metalloproteinase 1 
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN… Expand
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Metastatic tumor cells that actively migrate and invade surrounding tissues rely on invadopodia to degrade extracellular matrix… Expand
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Highly Cited
2003
Highly Cited
2003
Cancer cells are able to proliferate at accelerated rates within the confines of a three-dimensional (3D) extracellular matrix… Expand
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Review
2003
Review
2003
Matrix metalloproteinases (MMPs) are believed to play a pivotal role in malignant behavior of cancer cells such as rapid tumor… Expand
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Highly Cited
2002
Highly Cited
2002
Membrane-type 1 matrix metalloproteinase (MT1- MMP) localizes at the front of migrating cells and degrades the extracellular… Expand
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Highly Cited
2001
Highly Cited
2001
Migratory cells including invasive tumor cells frequently express CD44, a major receptor for hyaluronan and membrane-type 1… Expand
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Highly Cited
2001
Highly Cited
2001
A number of different matrix metalloproteinase (MMP) inhibitors have been developed as cytostatic and anti-angiogenic agents and… Expand
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Highly Cited
2001
Highly Cited
2001
Extracellular matrix metalloproteinase inducer (EMMPRIN; CD147) is a heavily glycosylated protein containing two immunoglobulin… Expand
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Highly Cited
2000
Highly Cited
2000
BackgroundMatrix metalloproteinases (MMPs) contribute to matrix remodeling in disease states such as tumor metastases… Expand
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Highly Cited
1997
Highly Cited
1997
Membrane type 1 matrix metalloproteinase (MT1-MMP) is expressed on cancer cell membranes and activates the zymogen of MMP-2… Expand
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Highly Cited
1997
Highly Cited
1997
Soluble proenzyme forms of the catalytic domains of membrane-type matrix metalloproteinases 1 and 2 (MT1-MMP and MT2-MMP) and a… Expand
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