membrane-type 1 matrix metalloproteinase

Known as: Membrane Type 1 Matrix Metalloproteinase, Metalloproteinase, MMP14, Membrane Type Matrix Metalloproteinase 1 
A transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the action of PROPROTEIN… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
05010019962018

Papers overview

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Highly Cited
2006
Highly Cited
2006
Metastatic tumor cells that actively migrate and invade surrounding tissues rely on invadopodia to degrade extracellular matrix… (More)
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Highly Cited
2003
Highly Cited
2003
Cancer cells are able to proliferate at accelerated rates within the confines of a three-dimensional (3D) extracellular matrix… (More)
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Highly Cited
2002
Highly Cited
2002
Membrane-type 1 matrix metalloproteinase (MT1- MMP) localizes at the front of migrating cells and degrades the extracellular… (More)
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Highly Cited
2001
Highly Cited
2001
Migratory cells including invasive tumor cells frequently express CD44, a major receptor for hyaluronan and membrane-type 1… (More)
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Highly Cited
2000
Highly Cited
2000
Membrane type-1 matrix metalloproteinase (MT1-MMP) is the prototypical member of a subgroup of membrane-anchored proteinases that… (More)
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Highly Cited
2000
Highly Cited
2000
Membrane-type matrix metalloproteinase I (MT1-MMP)-deficient mice were found to have severe defects in skeletal development and… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Matrix metalloproteinases (MMPs) are expressed in atherosclerotic plaques, where in their active form, they may… (More)
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Highly Cited
1999
Highly Cited
1999
Matrix metalloproteinase activity is instrumental in processes of cellular invasion. The interstitial invasion of endothelial… (More)
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Highly Cited
1997
Highly Cited
1997
Membrane type 1 matrix metalloproteinase (MT1-MMP) is expressed on cancer cell membranes and activates the zymogen of MMP-2… (More)
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Highly Cited
1996
Highly Cited
1996
It has been proposed that the cell-mediated activation of progelatinase A requires binding of the C-terminal domain of the… (More)
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